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Adenosine 5'-triphosphate: a P2-purinergic agonist in the myocardium.
  • G. Vassort
  • Medicine, Physics
  • Physiological reviews
  • 1 April 2001
ATP, besides an intracellular energy source, is an agonist when applied to a variety of different cells including cardiomyocytes. Sources of ATP in the extracellular milieu are multiple.Expand
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PKA phosphorylation activates the calcium release channel (ryanodine receptor) in skeletal muscle
The type 1 ryanodine receptor (RyR1) on the sarcoplasmic reticulum (SR) is the major calcium (Ca2+) release channel required for skeletal muscle excitation–contraction (EC) coupling. RyR1 function isExpand
  • 202
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Length and protein kinase A modulations of myocytes in cardiac myosin binding protein C-deficient mice.
OBJECTIVE Beta-adrenergic stimulation modulates cardiac contractility through protein kinase A (PKA), which phosphorylates proteins such as troponin I (cTnI) and C-protein (cMyBP-C). The relativeExpand
  • 132
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Cardiac alpha 1-adrenoceptors: an overview.
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Simvastatin triggers mitochondria-induced Ca2+ signaling alteration in skeletal muscle.
Statin drugs represent the major improvement in the treatment of hypercholesterolemia that constitutes the main origin of atherosclerosis, leading to coronary heart disease. Besides tremendousExpand
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Existence and role of a slow inward current during the frog atrial action potential
Zusammenfassung“Voltage clamp”-Untersuchungen wurden an feinen Frosch-Vorhof-Trabekeln durchgeführt. Sie zeigen:1.einen schnellen Einwärts-Natriumstrom, der Funktion des Potentials und der Zeit ist.Expand
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Role of T-type Ca2+ channels in the heart.
After the first demonstration 30 years ago that Ca2+ could permeate through two different channels, the occurrence and role of T-type Ca2+ current, ICaT have been the matter of hundreds ofExpand
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Effects of aldosterone on transient outward K+ current density in rat ventricular myocytes.
1. Aldosterone, a major ionic homeostasis regulator, might also regulate cardiac ion currents. Using the whole-cell patch-clamp technique, we investigated whether aldosterone affects theExpand
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Protein Kinase A Phosphorylation of the Cardiac Calcium Release Channel (Ryanodine Receptor) in Normal and Failing Hearts
The cardiac ryanodine receptor/calcium release channel (RyR2) on the sarcoplasmic reticulum (SR) comprises a macromolecular complex that includes a kinase and two phosphatases that are bound to theExpand
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Frequency-dependent increase in cardiac Ca2+ current is due to reduced Ca2+ release by the sarcoplasmic reticulum.
"Ca(2+)-current facilitation" describes several features of increase in current amplitude often associated with a reduction in inactivation rate. The aim of this study was to investigate theExpand
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