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cyclin-dependent protein kinase activity
Known as:
cdk-activating kinase activity
, cyclin-dependent protein kinase, intrinsic catalyst activity
, cyclin-dependent protein serine/threonine kinase activity
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Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate…
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National Institutes of Health
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Related topics
Related topics
15 relations
CDC2 Protein Kinase
CDK2 gene
CDK4 gene
CDK5 gene
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Broader (1)
Cell Cycle Control
Narrower (1)
cyclin binding
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Development of CDK-targeted scoring functions for prediction of binding affinity.
N. M. B. Levin
,
V. O. Pintro
,
Gabriela Bitencourt-Ferreira
,
Bruna Boldrini de Mattos
,
Ariadne de Castro Silvério
,
W. F. de Azevedo
Biophysical Chemistry
2018
Corpus ID: 46739164
2011
2011
CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast
Masayoshi Fukuura
,
Koji Nagao
,
C. Obuse
,
Tatsuro S. Takahashi
,
T. Nakagawa
,
H. Masukata
Molecular Biology of the Cell
2011
Corpus ID: 16461192
Study of the essential roles of CDK in initiation of DNA replication in fission yeast indicates that CDK phosphorylates Sld3 and…
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Highly Cited
2010
Highly Cited
2010
CDK inhibitor p21 is prosurvival in adriamycin-induced podocyte injury, in vitro and in vivo.
C. B. Marshall
,
Ronald D. Krofft
,
J. Pippin
,
S. Shankland
AJP - Renal Physiology
2010
Corpus ID: 16277167
In response to injury, the highly specialized and terminally differentiated glomerular visceral epithelial cell, or podocyte, may…
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2009
2009
Protein kinase C alpha‐dependent signaling mediates endometrial cancer cell growth and tumorigenesis
J. Haughian
,
Elaine M. Reno
,
Alicia M. Thorne
,
A. Bradford
International Journal of Cancer
2009
Corpus ID: 5232749
Endometrial cancer is the most common invasive gynecologic malignancy, yet molecular mechanisms and signaling pathways underlying…
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2008
2008
Multiple Cyclin Kinase Inhibitors Promote Bile Acid-induced Apoptosis and Autophagy in Primary Hepatocytes via p53-CD95-dependent Signaling*
G. Zhang
,
Margaret A. Park
,
+10 authors
P. Dent
Journal of Biological Chemistry
2008
Corpus ID: 8693594
Previously, using primary hepatocytes residing in early G1 phase, we demonstrated that expression of the cyclin-dependent kinase…
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Review
2004
Review
2004
The Use of CDK Inhibitors in Oncology: A Pharmaceutical Perspective
P. Fischer
Cell Cycle
2004
Corpus ID: 34985402
To date dozens of pharmacophores with CDK-inhibitory properties have been discovered and the first compounds possessing such…
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Review
2003
Review
2003
Peptidomimetic design of CDK inhibitors targeting the recruitment site of the cyclin subunit.
Campbell McInnes
,
M. Andrews
,
D. Zheleva
,
D. Lane
,
P. Fischer
Current Medicinal Chemistry - Anti-Cancer Agents
2003
Corpus ID: 1396705
The recognition of cyclin-dependent kinase (CDK)/cyclin complexes by various cell-cycle regulatory proteins, including certain…
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Highly Cited
1998
Highly Cited
1998
Mutated p21WAF1/CIP1/SDI1 lacking CDK-inhibitory activity fails to prevent apoptosis in human colorectal carcinoma cells
Yan-Ping Lu
,
N. Yamagishi
,
T. Yagi
,
H. Takebe
Oncogene
1998
Corpus ID: 45669990
Human colorectal tumor cell lines were established which express wildtype p21 or p21 with a mutation at codon 46 (Cys) or 140…
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Highly Cited
1997
Highly Cited
1997
Recent advances on cyclins, CDKs and CDK inhibitors.
C. Martín-Castellanos
,
Moreno
Trends in Cell Biology
1997
Corpus ID: 33778923
Highly Cited
1995
Highly Cited
1995
G2/M Transition Requires Multisite Phosphorylation of Oncoprotein 18 by Two Distinct Protein Kinase Systems (*)
N. Larsson
,
H. Melander
,
U. Marklund
,
rjan Osterman
,
M. Gullberg
Journal of Biological Chemistry
1995
Corpus ID: 19742833
Oncoprotein 18 (Op18) is a conserved cytosolic protein that is a target for both cell cycle and cell surface receptor-regulated…
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