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cyclin-dependent protein kinase activity

Known as: cdk-activating kinase activity, cyclin-dependent protein kinase, intrinsic catalyst activity, cyclin-dependent protein serine/threonine kinase activity 
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate… 
National Institutes of Health

Related topics

Related topics

15 relations
CDC2 Protein KinaseCDK2 geneCDK4 geneCDK5 gene

Broader (1)

Cell Cycle Control

Narrower (1)

cyclin binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Development of CDK-targeted scoring functions for prediction of binding affinity.
2011
2011
CDK promotes interactions of Sld3 and Drc1 with Cut5 for initiation of DNA replication in fission yeast
Study of the essential roles of CDK in initiation of DNA replication in fission yeast indicates that CDK phosphorylates Sld3 and… 
Highly Cited
2010
Highly Cited
2010
CDK inhibitor p21 is prosurvival in adriamycin-induced podocyte injury, in vitro and in vivo.
In response to injury, the highly specialized and terminally differentiated glomerular visceral epithelial cell, or podocyte, may… 
2009
2009
Protein kinase C alpha‐dependent signaling mediates endometrial cancer cell growth and tumorigenesis
Endometrial cancer is the most common invasive gynecologic malignancy, yet molecular mechanisms and signaling pathways underlying… 
2008
2008
Multiple Cyclin Kinase Inhibitors Promote Bile Acid-induced Apoptosis and Autophagy in Primary Hepatocytes via p53-CD95-dependent Signaling*
Previously, using primary hepatocytes residing in early G1 phase, we demonstrated that expression of the cyclin-dependent kinase… 
Review
2004
Review
2004
The Use of CDK Inhibitors in Oncology: A Pharmaceutical Perspective
To date dozens of pharmacophores with CDK-inhibitory properties have been discovered and the first compounds possessing such… 
Review
2003
Review
2003
Peptidomimetic design of CDK inhibitors targeting the recruitment site of the cyclin subunit.
The recognition of cyclin-dependent kinase (CDK)/cyclin complexes by various cell-cycle regulatory proteins, including certain… 
Highly Cited
1998
Highly Cited
1998
Mutated p21WAF1/CIP1/SDI1 lacking CDK-inhibitory activity fails to prevent apoptosis in human colorectal carcinoma cells
Human colorectal tumor cell lines were established which express wildtype p21 or p21 with a mutation at codon 46 (Cys) or 140… 
Highly Cited
1997
Highly Cited
1997
Recent advances on cyclins, CDKs and CDK inhibitors.
Highly Cited
1995
Highly Cited
1995
G2/M Transition Requires Multisite Phosphorylation of Oncoprotein 18 by Two Distinct Protein Kinase Systems (*)
Oncoprotein 18 (Op18) is a conserved cytosolic protein that is a target for both cell cycle and cell surface receptor-regulated… 
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