FAQ

cyclin-dependent protein kinase activity

Known as: cdk-activating kinase activity, cyclin-dependent protein kinase, intrinsic catalyst activity, cyclin-dependent protein serine/threonine kinase activity 
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate… (More)

Topic mentions per year

Topic mentions per year

1960-2018
010020019602018

Related topics

Related topics

16 relations
CDC2 Protein KinaseCDK2 geneCDK4 geneCDK5 gene
(More)

Broader (1)

Cell Cycle Control

Narrower (1)

cyclin binding

Related mentions per year

Related mentions per year

1949-2018
19401960198020002020
cyclin-dependent protein kinase activity
cyclin-dependent protein kinase regulator activity
Cell Cycle Control
Cyclin-Dependent Kinases
Cyclin-Dependent Kinase 4
CDC2 Protein Kinase

Papers overview

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Highly Cited
2006
Highly Cited
2006
An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor
The mechanism by which the epidermal growth factor receptor (EGFR) is activated upon dimerization has eluded definition. We find… (More)
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Highly Cited
2004
Highly Cited
2004
Cyclin-dependent kinases regulate the antiproliferative function of Smads.
Transforming growth factor-beta (TGF-beta) potently inhibits cell cycle progression at the G1 phase. Smad3 has a key function in… (More)
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Highly Cited
2001
Highly Cited
2001
Indirubins inhibit glycogen synthase kinase-3 beta and CDK5/p25, two protein kinases involved in abnormal tau phosphorylation in Alzheimer's disease. A property common to most cyclin-dependent kinase…
The bis-indole indirubin is an active ingredient of Danggui Longhui Wan, a traditional Chinese medicine recipe used in the… (More)
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Highly Cited
1999
Highly Cited
1999
The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts.
The widely prevailing view that the cyclin-dependent kinase inhibitors (CKIs) are solely negative regulators of cyclin-dependent… (More)
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Highly Cited
1997
Highly Cited
1997
Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator.
The nuclear factor kappaB (NF-kappaB) transcription factor is responsive to specific cytokines and stress and is often activated… (More)
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Highly Cited
1996
Highly Cited
1996
Flavopiridol induces G1 arrest with inhibition of cyclin-dependent kinase (CDK) 2 and CDK4 in human breast carcinoma cells.
Flavopiridol (L86-8275), a N-methylpiperidinyl, chlorophenyl flavone, can inhibit cell cycle progression in either G1 or G2 and… (More)
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Highly Cited
1996
Highly Cited
1996
Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc.
We show here that c-Myc antagonizes the cyclin-dependent kinase (CDK) inhibitor p27Kip1. p27 expressed from recombinant… (More)
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Highly Cited
1995
Highly Cited
1995
Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinases CDK4 and CDK6.
Cyclin D-dependent kinases act as mitogen-responsive, rate-limiting controllers of G1 phase progression in mammalian cells. Two… (More)
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Highly Cited
1994
Highly Cited
1994
The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA.
The p53 tumour-suppressor protein controls the expression of a gene encoding the p21 cyclin-dependent protein kinase (CDK… (More)
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Highly Cited
1994
Highly Cited
1994
Cell cycle expression and p53 regulation of the cyclin-dependent kinase inhibitor p21.
In normal human fibroblast cells, the primary cell cycle regulators, the cyclin-dependent kinases (CDKs), exist predominantly in… (More)
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