cyclin-dependent protein kinase activity

Known as: cdk-activating kinase activity, cyclin-dependent protein kinase, intrinsic catalyst activity, cyclin-dependent protein serine/threonine kinase activity 
Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate… (More)

Topic mentions per year

Topic mentions per year

1960-2018
010020019602018

Papers overview

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Highly Cited
2006
Highly Cited
2006
The mechanism by which the epidermal growth factor receptor (EGFR) is activated upon dimerization has eluded definition. We find… (More)
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Highly Cited
2004
Highly Cited
2004
Transforming growth factor-beta (TGF-beta) potently inhibits cell cycle progression at the G1 phase. Smad3 has a key function in… (More)
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Highly Cited
2001
Highly Cited
2001
The bis-indole indirubin is an active ingredient of Danggui Longhui Wan, a traditional Chinese medicine recipe used in the… (More)
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Highly Cited
1999
Highly Cited
1999
The widely prevailing view that the cyclin-dependent kinase inhibitors (CKIs) are solely negative regulators of cyclin-dependent… (More)
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Highly Cited
1997
Highly Cited
1997
The nuclear factor kappaB (NF-kappaB) transcription factor is responsive to specific cytokines and stress and is often activated… (More)
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Highly Cited
1996
Highly Cited
1996
Flavopiridol (L86-8275), a N-methylpiperidinyl, chlorophenyl flavone, can inhibit cell cycle progression in either G1 or G2 and… (More)
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Highly Cited
1996
Highly Cited
1996
We show here that c-Myc antagonizes the cyclin-dependent kinase (CDK) inhibitor p27Kip1. p27 expressed from recombinant… (More)
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Highly Cited
1995
Highly Cited
1995
Cyclin D-dependent kinases act as mitogen-responsive, rate-limiting controllers of G1 phase progression in mammalian cells. Two… (More)
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Highly Cited
1994
Highly Cited
1994
The p53 tumour-suppressor protein controls the expression of a gene encoding the p21 cyclin-dependent protein kinase (CDK… (More)
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Highly Cited
1994
Highly Cited
1994
In normal human fibroblast cells, the primary cell cycle regulators, the cyclin-dependent kinases (CDKs), exist predominantly in… (More)
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