Skip to search formSkip to main contentSkip to account menu

CDK2 gene

Known as: Cyclin Dependent Kinase 2 Gene, p33(CDK2), CYCLIN-DEPENDENT KINASE 2 
This gene is involved in G2/M cell cycle regulation.
National Institutes of Health

Related topics

Related topics

8 relations
CDK2 protein, humanCell Cycle ControlDNA ReplicationPhosphorylation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
DNA damage induces Chk1-dependent threonine-160 phosphorylation and activation of Cdk2
Abnormal centrosome numbers arise in tumours and can cause multipolar mitoses and genome instability. Cdk2 controls normal… 
2007
2007
Human TopBP1 Participates in Cyclin E/CDK2 Activation and Preinitiation Complex Assembly during G1/S Transition*
Human TopBP1 with eight BRCA1 C terminus domains has been mainly reported to be involved in DNA damage response pathways. Here we… 
Review
2006
Review
2006
Different Mechanisms of CDK5 and CDK2 Activation as Revealed by CDK5/p25 and CDK2/Cyclin A Dynamics*
A detailed analysis is presented of the dynamics of human CDK5 in complexes with the protein activator p25 and the purine-like… 
Highly Cited
2002
Highly Cited
2002
Pituitary Adenylate Cyclase Activating Polypeptide Anti-Mitogenic Signaling in Cerebral Cortical Progenitors Is Regulated by p57Kip2-Dependent CDK2 Activity
Generation of distinct cell types and numbers in developing cerebral cortex is subject to regulation by extracellular factors… 
Highly Cited
2002
Highly Cited
2002
A Novel, Extraneuronal Role for Cyclin-dependent Protein Kinase 5 (CDK5)
A number of cyclin-dependent protein kinase (CDK) inhibitors were tested for the ability to protect IPC-81 rat leukemic cells… 
Highly Cited
2002
Highly Cited
2002
DNA Damage Invokes Mismatch Repair-dependent Cyclin D1 Attenuation and Retinoblastoma Signaling Pathways to Inhibit CDK2*
DNA-damage evokes cell cycle checkpoints, which function to maintain genomic integrity. The retinoblastoma tumor suppressor (RB… 
Review
2001
Review
2001
Reduction of p12DOC-1 expression is a negative prognostic indicator in patients with surgically resected oral squamous cell carcinoma.
PURPOSE p12DOC-1 is a growth suppressor that negatively regulates cyclin-dependent kinase 2 (CDK2) activities. Expression of… 
Highly Cited
1997
Highly Cited
1997
Differential Phosphorylation of T-47D Human Breast Cancer Cell Substrates by D1-, D3-, E-, and A-type Cyclin-CDK Complexes*
The cyclin-dependent kinases (CDKs) promote cell cycle transitions in mammalian cells by phosphorylation of key substrates. To… 
1996
1996
Structural basis for chemical inhibition of CDK2.
The central role of cyclin-dependent kinases (CDKs) in cell cycle regulation makes them a promising target for discovering small… 
Highly Cited
1995
Highly Cited
1995
Constitutive Overexpression of CDK2 Inhibits Neuronal Differentiation of Rat Pheochromocytoma PC12 Cells (*)
Changes in the levels of cyclins A, D, and E, p21, and cyclin-dependent kinase 2 (CDK2) were examined in rat pheochromocytoma… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)