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Differential usage of non-homologous end-joining and homologous recombination in double strand break repair.
Repair of DNA double strand breaks (DSBs) plays a critical role in the maintenance of the genome. DSB arise frequently as a consequence of replication fork stalling and also due to the attack ofExpand
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Poly(ADP-Ribose) Polymerase 1 Accelerates Single-Strand Break Repair in Concert with Poly(ADP-Ribose) Glycohydrolase
ABSTRACT Single-strand breaks are the commonest lesions arising in cells, and defects in their repair are implicated in neurodegenerative disease. One of the earliest events during single-strandExpand
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Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells.
Cross-linking agents that induce DNA interstrand cross-links (ICL) are widely used in anticancer chemotherapy. Yeast genetic studies show that nucleotide excision repair (NER), Rad6/Rad18-dependentExpand
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Cdk activity couples epigenetic centromere inheritance to cell cycle progression.
Centromeres form the site of chromosome attachment to microtubules during mitosis. Identity of these loci is maintained epigenetically by nucleosomes containing the histone H3 variant CENP-A.Expand
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An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells
In vertebrates Cdk1 is required to initiate mitosis; however, any functionality of this kinase during S phase remains unclear. To investigate this, we generated chicken DT40 mutants, in which anExpand
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Parp‐1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells
Parp‐1 and Parp‐2 are activated by DNA breaks and have been implicated in the repair of DNA single‐strand breaks (SSB). Their involvement in double‐strand break (DSB) repair mediated by homologousExpand
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Reverse genetic studies of the DNA damage response in the chicken B lymphocyte line DT40.
In the 'post-genome' era, reverse genetics is one of the most informative and powerful means to investigate protein function. The chicken B lymphocyte line DT40 is widely used for reverse geneticsExpand
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Vertebrate POLQ and POLbeta cooperate in base excision repair of oxidative DNA damage.
Base excision repair (BER) plays an essential role in protecting cells from mutagenic base damage caused by oxidative stress, hydrolysis, and environmental factors. POLQ is a DNA polymerase, whichExpand
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Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells.
Proteasome inhibitors are novel antitumor agents against multiple myeloma and other malignancies. Despite the increasing clinical application, the molecular basis of their antitumor effect has beenExpand
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Akt/PKB suppresses DNA damage processing and checkpoint activation in late G2
Activated Akt suppresses checkpoint activation by cells in late G2: although they are able to detect DNA damage, the repair pathway is put on hold until mitosis is complete.
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