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cevimeline

Known as: Cevimelina, 2-methyspiro(1,3-oxathiolane-5,3)quinuclidine, cevimeline [Chemical/Ingredient] 
A cholinergic analogue with glandular secretion stimulatory activity. Cevimeline binds to and activates muscarinic receptors, thereby increasing the… Expand
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (5)

AF-102BCevimeline hydrochlorideEvoxacFKS 508
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Angle Closure GlaucomaAsthmaIritis

Broader (4)

Muscarinic AgonistsParasympathomimetic AgentsQuinuclidinesThiophenes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Cevimeline for the treatment of postirradiation xerostomia in patients with head and neck cancer.
PURPOSE To study the efficacy and safety of cevimeline in two double-blind trials (Studies 003 and 004) enrolling patients with… Expand
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Review
2006
Review
2006
The management of Sjögren's syndrome
Sjögren's syndrome is a chronic autoimmune disorder, characterized by lymphocytic infiltration and malfunction of the exocrine… Expand
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Review
2005
Review
2005
Salivary hypofunction and xerostomia: diagnosis and treatment.
Salivary gland hypofunction and complaints of xerostomia are common in elderly patients, irrespective of their living situation… Expand
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Highly Cited
2005
Highly Cited
2005
Identification of AQP5 in lipid rafts and its translocation to apical membranes by activation of M3 mAChRs in interlobular ducts of rat parotid gland.
Aquaporin-5 (AQP5), an apical plasma membrane (APM) water channel in salivary glands, lacrimal glands, and airway epithelium, has… Expand
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2005
2005
Effect of Cevimeline on Salivary Components in Patients with Sjögren Syndrome
The aim of this study is to clarify the effects of cevimeline on various components in human saliva, such as immunoglobulin A… Expand
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Review
2004
Review
2004
An update of the etiology and management of xerostomia.
Salivary gland disease gives rise to salivary gland enlargement, pain, and prolonged xerostomia (dry mouth). Xerostomia is the… Expand
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2004
2004
Therapeutic effect of cevimeline on dry eye in patients with Sjögren's syndrome: a randomized, double-blind clinical study.
PURPOSE Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by salivary and lacrimal glandular destruction… Expand
Is this relevant?
Highly Cited
2002
Highly Cited
2002
A double-blind, randomized, placebo-controlled study of cevimeline in Sjögren's syndrome patients with xerostomia and keratoconjunctivitis sicca.
OBJECTIVE To evaluate the safety and efficacy of 2 dosages of cevimeline for the treatment of xerostomia and keratoconjunctivitis… Expand
Is this relevant?
Review
2002
Review
2002
Current therapies for xerostomia and salivary gland hypofunction associated with cancer therapies
Abstract. In cancer patients, as in the general population, medication is the most common cause of xerostomia. In general, saliva… Expand
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Review
2000
Review
2000
Update in Sjögren syndrome.
Sjögren syndrome (SS), the second most common autoimmune rheumatic disease, refers to keratoconjunctivitis sicca and xerostomia… Expand
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