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cevimeline

Known as: Cevimelina, 2-methyspiro(1,3-oxathiolane-5,3)quinuclidine, cevimeline [Chemical/Ingredient] 
A cholinergic analogue with glandular secretion stimulatory activity. Cevimeline binds to and activates muscarinic receptors, thereby increasing the… 
National Institutes of Health

Related topics

Related topics

12 relations

Narrower (5)

AF-102BCevimeline hydrochlorideEvoxacFKS 508
Angle Closure GlaucomaAsthmaIritis

Broader (4)

Muscarinic AgonistsParasympathomimetic AgentsQuinuclidinesThiophenes

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Mode of interaction of 1,4-dioxane agonists at the M2 and M3 muscarinic receptor orthosteric sites.
2012
2012
Generation and functional analysis of monoclonal antibodies against the second extracellular loop of human M3 muscarinic acetylcholine receptor
The M3 muscarinic acetylcholine receptor (M3R) plays a crucial role in the activation of salivary and lachrymal glands. The M3R… 
2011
2011
Cevimeline-Induced Monophasic Salivation from the Mouse Submandibular Gland: Decreased Na+ Content in Saliva Results from Specific and Early Activation of Na+/H+ Exchange
Cevimeline and pilocarpine are muscarinic agonists used clinically to treat dry mouth. In this study, we explored fluid secretion… 
2009
2009
Cevimeline enhances the excitability of rat superior salivatory neurons.
Cevimeline, a therapeutic drug for xerostomia, is an agonist of muscarinic acetylcholine receptors (mAChRs), and directly… 
2006
2006
Assessment of the use of sialogogues in the clinical management of patients with xerostomia.
This study was conducted to assess the clinical efficacy and adverse effects of pilocarpine, bethanechol and cevimeline in… 
Review
2005
Review
2005
Recent advances in the management of ocular complications of sjögren’s syndrome
Sjögren’s syndrome (SS) is an autoimmune disorder, the principal ocular manifestation of which is decreased tear production… 
2005
2005
Two phase III clinical studies of cevimeline for post-radiation xerostomia in patients with head and neck cancer
5503 Background: Xerostomia is a frequent debilitating complication of head and neck cancer radiotherapy. Morbidities include… 
2004
2004
Traitement actuel de la xérostomie au cours du syndrome de Sjögren
2003
2003
Effects of Pilocarpine Hydrochloride and Cevimeline on Submandibular/ Sublingual Salivation in Rat Xerostomia Model Produced by X-Ray Irradiation
Summary The present study was performed to assess the effects of pilocarpine hydrochloride ((3S,4R)-3-ethyl-dihydro-4-[(1-methyl… 
Review
2000
Review
2000
Approaches to the treatment of Sjögren's syndrome.
Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by complaints of sicca symptoms (dry eye and mouth) and… 
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