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Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer.
Patients with squamous-cell carcinoma of the head and neck who received docetaxel plus cisplatin and fluorouracil induction chemotherapy plus chemoradiotherapy had a significantly longer survival than did patients who received cisPlatin and fluoride induction chemotherapyplus cheMoradiotherapy.
Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a…
The salivary microbiota as a diagnostic indicator of oral cancer: A descriptive, non-randomized study of cancer-free and oral squamous cell carcinoma subjects
- DL Mager, A. Haffajee, PM Devlin, C. Norris, M. Posner, J. Goodson
- MedicineJournal of Translational Medicine
- 7 July 2005
Counts of 3 of the 40 species tested, Capnocytophaga gingivalis, Prevotella melaninogenica and Streptococcus mitis, were elevated in the saliva of individuals with OSCC and when tested as diagnostic markers the 3 species were found to predict 80% of cancer cases (sensitivity) while excluding 83% of controls in the non-matched group.
Racial Survival Disparity in Head and Neck Cancer Results from Low Prevalence of Human Papillomavirus Infection in Black Oropharyngeal Cancer Patients
Worse OS for black SCCHN patients was driven by oropharyngeal cancer outcomes, and that for black oroph throat cancer patients by a lower prevalence of HPV infection, which has important implications for the etiology, prevention, prognosis, and treatment ofSCCHN.
Neutralization of HIV-1 by F105, a human monoclonal antibody to the CD4 binding site of gp120.
- M. Posner, L. Cavacini, C. Emes, J. Power, R. Byrn
- BiologyJournal of acquired immune deficiency syndromes
It is demonstrated that antibody interactions among different classes of antibodies may be important in in vivo neutralization of HIV-1 and comparison of F105 with other HMabs to the CD4 binding site and V3 loop provides an in vitro reference for in vivo activity.
American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer.
Evidence supports the use of larynx-preservation approaches for appropriately selected patients without a compromise in survival; however, no larynic cancer treatment approach offers a survival advantage compared with total laryngectomy and adjuvant therapy with rehabilitation as indicated.
Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial.
HPV+ OPC has a different biology compared with HPV- OPC; 5-year OS, PFS, and local-regional control are unprecedented; these results support the possibility of selectively reducing therapy and long-term morbidity in HPV+ O PC while preserving survival and approaching HPV- disease with more aggressive treatment.
Functional and immunologic characterization of human immunodeficiency virus type 1 envelope glycoproteins containing deletions of the major variable regions
The results indicate that, in addition to playing essential roles in the induction of membrane fusion, the major variable regions mask conserved neutralization epitopes of the HIV-1 gp120 glycoprotein from antibodies.
Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120
Co-crystal structures for two poorly neutralizing, CD4–binding site (CD4BS) antibodies, F105 and b13, in complexes with gp120 are determined, finding these conformations to be poorly compatible with the viral spike.
An IgG human monoclonal antibody that reacts with HIV-1/GP120, inhibits virus binding to cells, and neutralizes infection.
- M. Posner, T. Hideshima, T. Cannon, M. Mukherjee, K. Mayer, R. Byrn
- BiologyJournal of immunology
- 15 June 1991
F105 and the F105 epitope are potentially useful in therapy and in the design of peptide or anti-Id based vaccines; monitoring of the expression of the Id may prove useful in evaluating immune responses in infected individuals or vaccinated volunteers.