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Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer.
TLDR
Patients with squamous-cell carcinoma of the head and neck who received docetaxel plus cisplatin and fluorouracil induction chemotherapy plus chemoradiotherapy had a significantly longer survival than did patients who received cisPlatin and fluoride induction chemotherapyplus cheMoradiotherapy. Expand
Induction chemotherapy followed by concurrent chemoradiotherapy (sequential chemoradiotherapy) versus concurrent chemoradiotherapy alone in locally advanced head and neck cancer (PARADIGM): a
TLDR
Although survival results were good in both groups there was no difference noted between those patients treated with induction chemotherapy followed by chemoradiotherapy and those who received chemoradotherapy alone, and the addition of induction chemotherapy remains an appropriate approach for advanced disease with high risk for local or distant failure. Expand
American Society of Clinical Oncology clinical practice guideline for the use of larynx-preservation strategies in the treatment of laryngeal cancer.
TLDR
Evidence supports the use of larynx-preservation approaches for appropriately selected patients without a compromise in survival; however, no larynic cancer treatment approach offers a survival advantage compared with total laryngectomy and adjuvant therapy with rehabilitation as indicated. Expand
The salivary microbiota as a diagnostic indicator of oral cancer: A descriptive, non-randomized study of cancer-free and oral squamous cell carcinoma subjects
TLDR
Counts of 3 of the 40 species tested, Capnocytophaga gingivalis, Prevotella melaninogenica and Streptococcus mitis, were elevated in the saliva of individuals with OSCC and when tested as diagnostic markers the 3 species were found to predict 80% of cancer cases (sensitivity) while excluding 83% of controls in the non-matched group. Expand
Racial Survival Disparity in Head and Neck Cancer Results from Low Prevalence of Human Papillomavirus Infection in Black Oropharyngeal Cancer Patients
TLDR
Worse OS for black SCCHN patients was driven by oropharyngeal cancer outcomes, and that for black oroph throat cancer patients by a lower prevalence of HPV infection, which has important implications for the etiology, prevention, prognosis, and treatment ofSCCHN. Expand
Survival and human papillomavirus in oropharynx cancer in TAX 324: a subset analysis from an international phase III trial.
TLDR
HPV+ OPC has a different biology compared with HPV- OPC; 5-year OS, PFS, and local-regional control are unprecedented; these results support the possibility of selectively reducing therapy and long-term morbidity in HPV+ O PC while preserving survival and approaching HPV- disease with more aggressive treatment. Expand
Functional and immunologic characterization of human immunodeficiency virus type 1 envelope glycoproteins containing deletions of the major variable regions.
TLDR
The results indicate that, in addition to playing essential roles in the induction of membrane fusion, the major variable regions mask conserved neutralization epitopes of the HIV-1 gp120 glycoprotein from antibodies. Expand
Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120
TLDR
Co-crystal structures for two poorly neutralizing, CD4–binding site (CD4BS) antibodies, F105 and b13, in complexes with gp120 are determined, finding these conformations to be poorly compatible with the viral spike. Expand
Lack of association of alcohol and tobacco with HPV16-associated head and neck cancer.
TLDR
Alcohol or tobacco use does not further increase risk of HPV16-associated pharyngeal cancer, and HPV16 seropositivity was associated with a 30-fold increased risk of pharynGEal cancer among light drinkers or never smokers. Expand
Dose to larynx predicts for swallowing complications after intensity-modulated radiotherapy.
TLDR
Aspiration and stricture are common side effects after intensity-modulated radiotherapy for head-and-neck squamous cell carcinoma and the dose given to the larynx and inferior constrictors correlated with these side effects. Expand
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