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AF-102B

Known as: AF 102B, AF102B 
 
National Institutes of Health

Papers overview

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Review
2007
Review
2007
M1 muscarinic receptors (M1 mAChRs) play a role in an apparent linkage of three major hallmarks of Alzheimer’s disease (AD… Expand
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Highly Cited
2000
Highly Cited
2000
β‐Amyloid (Aβ) deposits in diffuse and compact senile plaques in the brain are one of the defining histopathological features of… Expand
Highly Cited
1998
Highly Cited
1998
Abstract: Full and functionally selective M1 muscarinic agonists (carbachol and AF102B, respectively) activate secretion of the… Expand
Highly Cited
1996
Highly Cited
1996
Abstract: Hyperphosphorylated τ proteins are the principal fibrous component of the neurofibrillary tangle pathology in Alzheimer… Expand
Highly Cited
1994
Highly Cited
1994
Three radiolabeled nicotinic receptor agonists were examined for their binding characteristics and for inhibition by cholinergic… Expand
Highly Cited
1994
Highly Cited
1994
Activation of transfected muscarinic m1 acetylcholine receptors (m1AChR) has been linked to several signal transduction pathways… Expand
Highly Cited
1993
Highly Cited
1993
In recent years muscarinic receptor agonists and cholinesterase inhibitors have been developed for the treatment of Alzheimer's… Expand
Highly Cited
1991
Highly Cited
1991
AF102B [(+-)-cis-2-methyl-spiro(1,3-oxathiolane-5,3')quinuclidine], a structurally rigid analog of acetylcholine, was… Expand
Highly Cited
1989
Highly Cited
1989
A dialysis loop cannula was implanted into rat striatum under anesthetized condition, and the area was perfused with Ringer's… Expand
Highly Cited
1988
Highly Cited
1988
The effects of oxotremorine and AF102B (cis-2-methylspiro-(1,3-oxathiolane-5,3')-quinuclidine), a novel M1-selective muscarinic… Expand