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Participation of thromboxane A2 in the cough response in guinea‐pigs: antitussive effect of ozagrel
TLDR
Results show that TXA2 modulates the capsaicin‐induced cough response by increasing capsaicIn‐sensitivity. Expand
New hyperprolactinemia and anovulation model in common marmoset (Callithrix jacchus) and effect of cabergoline.
TLDR
It is suggested that, in this anovulatory model in common marmosets, cabergoline has a potent and long-lasting action as a dopamine D2 receptor agonist, and thus could be a useful drug for the treatment of galactorrhea and hyperprolactinemic amenorrhea and/or anovulation. Expand
Functional Characterization of β-adrenoceptor Subtypes in the Canine and Rat Lower Urinary Tract
TLDR
In the dog the relaxing effects of isoprenaline in the distal urethra were about half those seen in the detrusor and trigone, and the maximal relaxation to each agonist wa... Expand
Oxcarbazepine antinociception in animals with inflammatory pain or painful diabetic neuropathy
TLDR
It is reported that currently available analgesics have hardly any ameliorating effect on painful diabetic neuropathy, and the mechanisms underlying these disorders are not yet well defined. Expand
Inhibitory effect of oxcarbazepine on high-frequency firing in peripheral nerve fibers.
TLDR
Results indicate that oxcarbazepine inhibits the generation of high-frequency firing without affecting impulse conduction, and suggest that this drug may be useful against neuropathic pain and paresthesia. Expand
Effects of dopamine d2 receptor agonists in a pituitary transplantation‐induced hyperprolactinaemia/anovulation model in rats
TLDR
The effects of hyperprolactinaemia, induced by transplantation of anterior pituitary glands under the kidney capsule in female rats, on the relationship between serum and pituitaries concentrations of the gonadotropins and on the oestrous cycle are investigated. Expand
Rat model of the hypercalcaemia induced by parathyroid hormone-related protein: characteristics of three bisphosphonates.
TLDR
Data indicated that clodronate and pamidronate not only decrease the plasma Ca2+ concentration but also improve the renal dysfunction induced by hypercalcaemia. Expand
Cardiovascular effects of KUR-1246, a new tetrahydronaphthalen derivative beta2-adrenoceptor agonist and a selective uterine relaxant.
TLDR
The effects of KUR-1246 in conscious dogs on the cardiovascular system appear to be limited to changes in blood pressure and heart rate, and it is unlikely to provoke ventricular arrhythmias by delaying the ventricular repolarization. Expand
Effect of a thromboxane A2 synthetase inhibitor (OKY-046.HCl) on airway hyperresponsiveness in guinea pigs.
TLDR
Results suggest that OKY-046.HCl inhibits airway hyperresponsiveness by suppressing TXA2 generation and will be a new antiasthmatic drug. Expand
Clodronate stimulates osteoblast differentiation in ST2 and MC3T3-E1 cells and rat organ cultures.
TLDR
The data suggest that clodronate acts directly on mesenchymal cells to enhance osteoblast differentiation, and this effect may be partly expressed through inhibition of protein Tyr phosphatase and/or Ser/Throsphatase activity. Expand
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