caspase

Known as: cystein protease, Caspases [Chemical/Ingredient], Peptidase Family C14 
Caspases are a family of intracellular cysteine proteinases involved in inflammation and apoptosis. These enzymes appear to be involved in the… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Protease biology is intimately linked to the functional consequences of substrate cleavage events. Human caspases are a family of… (More)
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Highly Cited
2015
Highly Cited
2015
Caspases are a family of endoproteases that provide critical links in cell regulatory networks controlling inflammation and cell… (More)
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Highly Cited
2004
Highly Cited
2004
Specific adaptors regulate the activation of initiator caspases; for example, FADD and Apaf-1 engage caspases 8 and 9… (More)
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Review
1999
Review
1999
Caspases are crucial mediators of programmed cell death (apoptosis). Among them, caspase-3 is a frequently activated death… (More)
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Review
1999
Review
1999
Caspases play an essential role during apoptotic cell death. These enzymes define a new class of cysteine proteases and comprise… (More)
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Review
1998
Review
1998
Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this… (More)
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Highly Cited
1998
Highly Cited
1998
Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt… (More)
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Highly Cited
1998
Highly Cited
1998
The homeostasis of animals is regulated not only by the growth and differentiation of cells, but also by cell death through a… (More)
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Highly Cited
1998
Highly Cited
1998
Mutation of Caspase 9 (Casp9) results in embryonic lethality and defective brain development associated with decreased apoptosis… (More)
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Review
1997
Review
1997
Apoptosis is a major form of cell death, characterized initially by a series of stereotypic morphological changes. In the… (More)
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