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caspase

Known as: cystein protease, Caspases [Chemical/Ingredient], Peptidase Family C14 
Caspases are a family of intracellular cysteine proteinases involved in inflammation and apoptosis. These enzymes appear to be involved in the… 
National Institutes of Health

Related topics

Related topics

39 relations
ApoptosisCaspase GeneCysteine Protease GenesEnzyme Gene

Narrower (21)

BromelainsCalpainCasp11 protein, mouseCathepsin H

Broader (2)

Cysteine EndopeptidasesEndopeptidases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Role of Bcl-2 family proteins and caspases in the regulation of apoptosis
Apoptosis, or programmed cell death, plays a pivotal role in the elimination of unwanted, damaged, or infected cells in… 
Review
2005
Review
2005
Caspases: pharmacological manipulation of cell death.
Caspases, a family of cysteine proteases, play a central role in apoptosis. During the last decade, major progress has been made… 
Review
2004
Review
2004
Death receptor-induced cell killing.
Review
2003
Review
2003
A decade of caspases
Caspases are a family of cysteine proteases that play important roles in regulating apoptosis. A decade of research has generated… 
Review
2001
Review
2001
Life-or-death decisions by the Bcl-2 protein family.
Highly Cited
2001
Highly Cited
2001
Human mature red blood cells express caspase-3 and caspase-8, but are devoid of mitochondrial regulators of apoptosis
Although proteases of the caspase family are essential mediators of apoptosis in nucleated cells, in anucleate cells their… 
Highly Cited
2001
Highly Cited
2001
Dimer formation drives the activation of the cell death protease caspase 9
A critical step in the induction of apoptosis is the activation of the apoptotic initiator caspase 9. We show that at its normal… 
Highly Cited
2000
Highly Cited
2000
Dual Role of Caspase-11 in Mediating Activation of Caspase-1 and Caspase-3 under Pathological Conditions
Caspase-11, a member of the murine caspase family, has been shown to be an upstream activator of caspase-1 in regulating cytokine… 
Highly Cited
1999
Highly Cited
1999
Caspase-9 and APAF-1 form an active holoenzyme.
Autocatalytic activation of initiator caspases is the link between pro-apoptotic signals and the destruction machinery of… 
Highly Cited
1998
Highly Cited
1998
An Induced Proximity Model for Caspase-8 Activation*
The assembly of the CD-95 (Fas/Apo-1) receptor death-inducing signaling complex occurs in a hierarchical manner; the death domain… 
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