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caspase
Known as:
cystein protease
, Caspases [Chemical/Ingredient]
, Peptidase Family C14
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Caspases are a family of intracellular cysteine proteinases involved in inflammation and apoptosis. These enzymes appear to be involved in the…
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National Institutes of Health
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Related topics
Related topics
39 relations
Apoptosis
Caspase Gene
Cysteine Protease Genes
Enzyme Gene
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Narrower (21)
Bromelains
Calpain
Casp11 protein, mouse
Cathepsin H
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Broader (2)
Cysteine Endopeptidases
Endopeptidases
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2015
Highly Cited
2015
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Jianjin Shi
,
Yue Zhao
,
+7 authors
F. Shao
Nature
2015
Corpus ID: 4407455
Inflammatory caspases (caspase-1, -4, -5 and -11) are critical for innate defences. Caspase-1 is activated by ligands of various…
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Review
2013
Review
2013
Caspase functions in cell death and disease.
D. Mcilwain
,
T. Berger
,
T. Mak
Cold Spring Harbor Perspectives in Biology
2013
Corpus ID: 39807718
Caspases are a family of endoproteases that provide critical links in cell regulatory networks controlling inflammation and cell…
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Review
2004
Review
2004
Molecular mechanisms of caspase regulation during apoptosis
S. Riedl
,
Yigong Shi
Nature reviews. Molecular cell biology
2004
Corpus ID: 19498556
Caspases, which are the executioners of apoptosis, comprise two distinct classes, the initiators and the effectors. Although…
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Review
1999
Review
1999
Emerging roles of caspase-3 in apoptosis
A. Porter
,
R. Jänicke
Cell Death and Differentiation
1999
Corpus ID: 36288702
Caspases are crucial mediators of programmed cell death (apoptosis). Among them, caspase-3 is a frequently activated death…
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Highly Cited
1999
Highly Cited
1999
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
A. Brunet
,
A. Bonni
,
+7 authors
M. Greenberg
Cell
1999
Corpus ID: 14506473
Review
1998
Review
1998
Caspases: enemies within.
Nancy A. Thornberry
,
Y. Lazebnik
Science
1998
Corpus ID: 9678069
Apoptosis, an evolutionarily conserved form of cell suicide, requires specialized machinery. The central component of this…
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Highly Cited
1998
Highly Cited
1998
Regulation of cell death protease caspase-9 by phosphorylation.
M. Cardone
,
N. Roy
,
+5 authors
John Calvin Reed
Science
1998
Corpus ID: 40630868
Caspases are intracellular proteases that function as initiators and effectors of apoptosis. The kinase Akt and p21-Ras, an Akt…
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Highly Cited
1998
Highly Cited
1998
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD
M. Enari
,
H. Sakahira
,
H. Yokoyama
,
K. Okawa
,
A. Iwamatsu
,
S. Nagata
Nature
1998
Corpus ID: 4407426
The homeostasis of animals is regulated not only by the growth and differentiation of cells, but also by cell death through a…
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Highly Cited
1998
Highly Cited
1998
Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis*
R. Jänicke
,
M. L. Sprengart
,
M. R. Wati
,
A. Porter
Journal of Biological Chemistry
1998
Corpus ID: 25644054
Interleukin 1β-converting enzyme-like proteases (caspases) are crucial components of cell death pathways. Among the caspases…
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Review
1997
Review
1997
Caspases: the executioners of apoptosis.
G. Cohen
Biochemical Journal
1997
Corpus ID: 25236351
Apoptosis is a major form of cell death, characterized initially by a series of stereotypic morphological changes. In the…
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