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Calpain

Known as: Papain-Like Cysteine Protease, Neutral Proteinase, Calcium-Dependent, Proteinase, Calcium-Dependent Neutral 
Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from… 
National Institutes of Health

Related topics

Related topics

30 relations

Narrower (14)

CAPN1 protein, humanCAPN11 protein, humanCalpain ICalpain II
Cysteine Protease GenesEnzyme GeneHydrolysisIn Blood

Broader (1)

caspase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2004
Review
2004
The giant protein titin: a major player in myocardial mechanics, signaling, and disease.
The sarcomere contains, in addition to thin and thick filaments, a filament composed of the giant protein titin (also known as… 
Highly Cited
2001
Highly Cited
2001
Disruption of the Mouse μ-Calpain Gene Reveals an Essential Role in Platelet Function
ABSTRACT Conventional calpains are ubiquitous calcium-regulated cysteine proteases that have been implicated in cytoskeletal… 
Review
1993
Review
1993
Medicinal and therapeutic value of the shiitake mushroom.
Highly Cited
1991
Highly Cited
1991
Degradation of Microtubule‐Associated Protein 2 and Brain Spectrin by Calpain: A Comparative Study
Abstract: The in vitro degradation of microtubule‐associated protein 2 (MAP‐2) and spectrin by the calcium‐dependent neutral… 
Highly Cited
1988
Highly Cited
1988
Protease Ti, a new ATP-dependent protease in Escherichia coli, contains protein-activated ATPase and proteolytic functions in distinct subunits.
Highly Cited
1987
Highly Cited
1987
Isolation and structural studies of the intact scrapie agent protein.
Highly Cited
1985
Highly Cited
1985
On the association of glycoprotein Ib and actin-binding protein in human platelets
Glycoprotein (GP) Ib was purified from lysates of human platelets prepared in the presence or absence of inhibitors of the… 
Highly Cited
1982
Highly Cited
1982
Characterization of a brain calcium-activated protease that degrades neurofilament proteins.
A Ca2+-dependent protease was prepared from rat brain by using DEAE-Sephadex, Sephadex G-200, and substrate affinity… 
Highly Cited
1982
Highly Cited
1982
The stimulation of protein degradation in muscle by Ca2+ is mediated by prostaglandin E2 and does not require the calcium-activated protease.
Highly Cited
1981
Highly Cited
1981
Limited autolysis of Ca2+-activated neutral protease (CANP) changes its sensitivity to Ca2+ ions.
Ca2+-activated neutral protease (CANP) usually requires mM Ca2+ for activation. The sensitivity of CANP to Ca2+ is greatly… 
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