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Calpain

Known as: Papain-Like Cysteine Protease, Neutral Proteinase, Calcium-Dependent, Proteinase, Calcium-Dependent Neutral 
Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from… 
National Institutes of Health

Related topics

Related topics

30 relations

Narrower (14)

CAPN1 protein, humanCAPN11 protein, humanCalpain ICalpain II
Cysteine Protease GenesEnzyme GeneHydrolysisIn Blood

Broader (1)

caspase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Vimentin-Dependent Spatial Translocation of an Activated MAP Kinase in Injured Nerve
Review
2004
Review
2004
The giant protein titin: a major player in myocardial mechanics, signaling, and disease.
The sarcomere contains, in addition to thin and thick filaments, a filament composed of the giant protein titin (also known as… 
Highly Cited
2003
Highly Cited
2003
Inhibition of Calpains Prevents Neuronal and Behavioral Deficits in an MPTP Mouse Model of Parkinson's Disease
The molecular mechanisms mediating degeneration of midbrain dopamine neurons in Parkinson's disease (PD) are poorly understood… 
Highly Cited
2002
Highly Cited
2002
Calpain Activation in Huntington's Disease
Huntington's disease (HD) is a neurodegenerative disorder caused by a CAG expansion that results in elongation of the… 
Highly Cited
2001
Highly Cited
2001
Synergistic Activation of Caspase-3 by m-Calpain after Neonatal Hypoxia-Ischemia
The relative contributions of apoptosis and necrosis in brain injury have been a matter of much debate. Caspase-3 has been… 
Highly Cited
2000
Highly Cited
2000
Disruption of the Murine Calpain Small Subunit Gene, Capn4: Calpain Is Essential for Embryonic Development but Not for Cell Growth and Division
ABSTRACT Calpains are a family of Ca2+-dependent intracellular cysteine proteases, including the ubiquitously expressed μ- and m… 
Highly Cited
1997
Highly Cited
1997
Regulation of Cell Migration by the Calcium-dependent Protease Calpain*
Integrin receptors play an important role during cell migration by mediating linkages and transmitting forces between the… 
Highly Cited
1996
Highly Cited
1996
The Crystal Structure of Hepatitis C Virus NS3 Proteinase Reveals a Trypsin-like Fold and a Structural Zinc Binding Site
Highly Cited
1994
Highly Cited
1994
Calpain activation in apoptosis
Programmed cell death is an active process wherein the cell initiates a sequence of events culminating in the fragmentation of… 
Highly Cited
1983
Highly Cited
1983
Proteolytic activation of calcium-activated, phospholipid-dependent protein kinase by calcium-dependent neutral protease.
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