• Publications
  • Influence
PECAM-1 (CD31) cloning and relation to adhesion molecules of the immunoglobulin gene superfamily.
An antibody to a platelet integral membrane glycoprotein was found to cross-react with the previously identified CD31 myelomonocytic differentiation antigen and with hec7, an endothelial cell proteinExpand
  • 712
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The biology of PECAM-1.
  • P. Newman
  • Medicine, Biology
  • The Journal of clinical investigation
  • 1997
A bobbin for a lock stitch sewing machine is disclosed having on one flange an annular protuberance concentric with the center of rotation of the bobbin and having on opposite sides of said oneExpand
  • 618
  • 17
Integrins: dynamic scaffolds for adhesion and signaling in platelets.
The major platelet integrin, alphaIIbbeta3, is required for platelet interactions with proteins in plasma and the extracellular matrices (ECMs) that are essential for platelet adhesion andExpand
  • 526
  • 16
The human platelet alloantigens, PlA1 and PlA2, are associated with a leucine33/proline33 amino acid polymorphism in membrane glycoprotein IIIa, and are distinguishable by DNA typing.
The human platelet alloantigens, PlA1 and PlA2, comprise a diallelic antigen system located on a component of the platelet fibrinogen receptor, membrane glycoprotein (GP) IIIa. Of the known plateletExpand
  • 381
  • 14
Molecular and functional aspects of PECAM-1/CD31.
Among vascular cell adhesion molecules, platelet-endothelial cell adhesion molecule (PECAM-1/CD31) has the distinctive feature of being expressed on several of the major cell types associated withExpand
  • 245
  • 14
Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule
PECAM-1 is a 130-120-kD integral membrane glycoprotein found on the surface of platelets, at endothelial intercellular junctions in culture, and on cells of myeloid lineage. Previous studies haveExpand
  • 486
  • 12
Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31): alternatively spliced, functionally distinct isoforms expressed during mammalian cardiovascular development.
The establishment of the cardiovascular system represents an early, critical event essential for normal embryonic development. An important component of vascular ontogeny is the differentiation andExpand
  • 234
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Signal transduction pathways mediated by PECAM-1: new roles for an old molecule in platelet and vascular cell biology.
  • P. Newman, D. Newman
  • Medicine, Biology
  • Arteriosclerosis, thrombosis, and vascular…
  • 1 June 2003
Recent studies of platelet endothelial cell adhesion molecule-1 (PECAM-1 [CD31])-deficient mice have revealed that this molecule plays an important role in controlling the activation and survival ofExpand
  • 347
  • 10
CD31 expressed on distinctive T cell subsets is a preferential amplifier of beta 1 integrin-mediated adhesion
The CD31 (platelet endothelial cell adhesion molecule-1 [PECAM- 1]/endothelial cell adhesion molecule [endoCAM]) molecule expressed on leukocytes, platelets, and endothelial cells is postulated toExpand
  • 246
  • 9
Characterization of Phosphotyrosine Binding Motifs in the Cytoplasmic Domain of Platelet/Endothelial Cell Adhesion Molecule-1 (PECAM-1) That Are Required for the Cellular Association and Activation
Recent studies have shown that the Src homology-2 (SH2) domain-containing protein-tyrosine phosphatase, SHP-2, associates with the cytoplasmic domain of PECAM-1 as it becomes tyrosine-phosphorylatedExpand
  • 145
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