Potent neuroprotectants linked to bifunctional inhibition.

  title={Potent neuroprotectants linked to bifunctional inhibition.},
  author={Valina L Dawson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={96 19},
  • Valina L Dawson
  • Published 1999 in
    Proceedings of the National Academy of Sciences…
Neuronal death after ischemic or traumatic injury is mediated, in large part, by excitotoxicity. Originally, it was thought that cell damage by ischemiayreperfusion and other forms of neuronal insults was caused by calcium-mediated activation of phospholipases and proteases, leading to release of free fatty acids and their metabolites, the concomitant generation of reactive oxygen species, and the degradation of cytoskeletal proteins. In an effort to limit the formation of reactive oxygen… CONTINUE READING


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