caspase-6

Known as: MCH2, Apoptotic Protease Mch-2, Caspase 6 
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 7; CASPASE 8; and CASPASE… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
Naturally occurring axonal pruning and neuronal cell death help to sculpt neuronal connections during development, but their… (More)
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Highly Cited
2008
Highly Cited
2008
Members of the caspase family of cysteine proteases play central roles in coordinating the stereotypical events that occur during… (More)
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Highly Cited
2006
Highly Cited
2006
Cleavage of huntingtin (htt) has been characterized in vitro, and accumulation of caspase cleavage fragments represents an early… (More)
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Highly Cited
2004
Highly Cited
2004
Previously, we have shown that caspase-6 but not caspase-3 is activated by serum deprivation and induces a protracted cell death… (More)
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Highly Cited
2002
Highly Cited
2002
To study the role of caspase-6 during nuclear disassembly, we generated a chicken DT40 cell line in which both alleles of the… (More)
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Highly Cited
2002
Highly Cited
2002
Little is known about how a cell's apoptotic threshold is controlled after exposure to chemotherapy, although the p53 tumor… (More)
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Highly Cited
2001
Highly Cited
2001
Apoptosis is orchestrated by a family of cysteine proteases known as the caspases. Fourteen mammalian caspases have been… (More)
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Highly Cited
1999
Highly Cited
1999
Caspase-3 initiates apoptotic DNA fragmentation by proteolytically inactivating DFF45 (DNA fragmentation factor-45)/ICAD… (More)
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Highly Cited
1998
Highly Cited
1998
We report here the purification of a cytosolic protein that induces cytochrome c release from mitochondria in response to caspase… (More)
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Highly Cited
1997
Highly Cited
1997
Keratins 8 (K8) and 18 (K18) are major components of intermediate filaments (IFs) of simple epithelial cells and tumors derived… (More)
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