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CASP6 gene

Known as: caspase 6, CASPASE 6, APOPTOSIS-RELATED CYSTEINE PROTEASE, MCH2 
This gene is involved in the execution of apoptosis.
National Institutes of Health

Related topics

Related topics

5 relations
ApoptosisHydrolysisProteolysiscaspase-6

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CASP6 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Death ligand concentration and the membrane proximal signaling module regulate the type 1/type 2 choice in apoptotic death signaling
Apoptotic death pathways are frequently activated by death ligand induction and subsequent activation of the membrane proximal… 
Highly Cited
2012
Highly Cited
2012
Transgenic Mouse Model Expressing the Caspase 6 Fragment of Mutant Huntingtin
Huntington's disease (HD) is caused by a polyglutamine expansion in the Huntingtin (Htt) protein. Proteolytic cleavage of Htt… 
2011
2011
Transgenic mice expressing caspase-6-derived N-terminal fragments of mutant huntingtin develop neurologic abnormalities with predominant cytoplasmic inclusion pathology composed largely of a smaller…
Recent studies have implicated an N-terminal caspase-6 cleavage product of mutant huntingtin (htt) as an important mediator of… 
Highly Cited
2010
Highly Cited
2010
Amyloid Precursor Protein Cleavage-Dependent and -Independent Axonal Degeneration Programs Share a Common Nicotinamide Mononucleotide Adenylyltransferase 1-Sensitive Pathway
Axonal degeneration is a hallmark of many debilitating neurological disorders and is thought to be regulated by mechanisms… 
Highly Cited
2005
Highly Cited
2005
Comparative modeling in CASP6 using consensus approach to template selection, sequence‐structure alignment, and structure assessment
Along with over 150 other groups we have tested our template‐based protein structure prediction approach by submitting models for… 
2005
2005
Protein structure prediction in CASP6 using CHIMERA and FAMS
In CASP6, the CHIMERA‐group predicted full‐atom models of all targets using SKE‐CHIMERA, a Web‐user interface system for protein… 
Highly Cited
2001
Highly Cited
2001
SATB1 Cleavage by Caspase 6 Disrupts PDZ Domain-Mediated Dimerization, Causing Detachment from Chromatin Early in T-Cell Apoptosis
ABSTRACT SATB1 is expressed primarily in thymocytes and orchestrates temporal and spatial expression of a large number of genes… 
Highly Cited
2001
Highly Cited
2001
Cloning and sequencing of caspase 6 in rainbow trout, Oncorhynchus mykiss, and analysis of its expression under conditions known to induce apoptosis.
1999
1999
News & Views (CC-FF)
the APP cytoplasmic tail then creates a truncated APP product that is more susceptible to Ab production. This results in a… 
1999
1999
News & Views (CC-FF)
  • 1999
  • Corpus ID: 51913792
the APP cytoplasmic tail then creates a truncated APP product that is more susceptible to Ab production. This results in a… 
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