Fibroblast growth factor receptor 3 inhibition by short hairpin RNAs leads to apoptosis in multiple myeloma.

@article{Zhu2005FibroblastGF,
  title={Fibroblast growth factor receptor 3 inhibition by short hairpin RNAs leads to apoptosis in multiple myeloma.},
  author={Lijun Zhu and George Somlo and Bingsen Zhou and Jimin Shao and Victoria H Bedell and Marilyn L. Slovak and Xiyong Liu and Jianhong Luo and Yun Yen},
  journal={Molecular cancer therapeutics},
  year={2005},
  volume={4 5},
  pages={787-98}
}
The presence of t(4;14)(p16.3;q32.3) in multiple myeloma cells results in dysregulated expression of the fibroblast growth factor receptor 3 (FGFR3). FGFR3 acts as an oncogene to promote multiple myeloma cell proliferation and antiapoptosis. These encourage the clinical development of FGFR3-specific inhibitors. Three short hairpin RNAs (shRNA) targeting different sites of FGFR3 were selected and subsequently transfected into KMS-11, OPM-2, and NCI-H929 human myeloma cell lines, all of which are… CONTINUE READING