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caspase-3

Known as: CPP32B, CASP-3, CPP32 
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this… 
National Institutes of Health

Related topics

Related topics

40 relations
Alzheimer's DiseaseAlzheimer's Disease Pathway KEGGApoptosisCASP2 protein, human

Narrower (2)

Casp3 protein, ratProcaspase-3

Broader (1)

Cysteine Endopeptidases

Papers overview

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Highly Cited
2011
Highly Cited
2011
miR-203 reverses chemoresistance in p53-mutated colon cancer cells through downregulation of Akt2 expression.
Highly Cited
2002
Highly Cited
2002
Ceramide and Reactive Oxygen Species Generated by H2O2 Induce Caspase-3-independent Degradation of Akt/Protein Kinase B*
This study was designed to elucidate the mechanisms leading to down-regulation of the Akt/protein kinase B (PKB) survival pathway… 
Highly Cited
2000
Highly Cited
2000
Resistance to CD95/Fas‐induced and ceramide‐mediated apoptosis of human melanoma cells is caused by a defective mitochondrial cytochrome c release
Highly Cited
1999
Highly Cited
1999
Inhibition of caspases prevents cell death of hippocampal CA1 neurons, but not impairment of hippocampal long-term potentiation following global ischemia
Highly Cited
1999
Highly Cited
1999
Activation of Caspase-3 in the Retina of Transgenic Rats with the Rhodopsin Mutation S334ter during Photoreceptor Degeneration
The role of caspase-3 in photoreceptor degeneration was examined in a line of transgenic rats that carry a rhodopsin mutation… 
Highly Cited
1998
Highly Cited
1998
Co-localization of the cysteine protease caspase-3 with apoptotic myocytes after in vivo myocardial ischemia and reperfusion in the rat.
The aim of our study was to characterize the temporal relationship of apoptosis to regional myocardial ischemia and reperfusion… 
Highly Cited
1998
Highly Cited
1998
Inhibition of sphingolipid induced apoptosis by caspase inhibitors indicates that sphingosine acts in an earlier part of the apoptotic pathway than ceramide
Highly Cited
1996
Highly Cited
1996
Type I Insulin-like Growth Factor Receptor Activation Regulates Apoptotic Proteins*
Activation of the type I insulin-like growth factor receptor (IGF-IR) blocks osmotic mediated programmed cell death (PCD) in… 
Highly Cited
1996
Highly Cited
1996
DNA-dependent Protein Kinase Is a Target for a CPP32-like Apoptotic Protease*
We demonstrate that the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs) is specifically, proteolytically cleaved… 
Highly Cited
1996
Highly Cited
1996
Bcl-2 and adenovirus E1B 19 kDA protein prevent E1A-induced processing of CPP32 and cleavage of poly(ADP-ribose) polymerase.
The E1A oncoproteins of adenovirus type 5 are potent inducers of apoptotic cell death. To manifest growth promoting and… 
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