caspase-3

Known as: CPP32B, CASP-3, CPP32 
A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this… (More)
National Institutes of Health

Papers overview

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Highly Cited
2000
Highly Cited
2000
Huntington disease is an autosomal dominant neurodegenerative disease with no effective treatment. Minocycline is a tetracycline… (More)
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Review
1999
Review
1999
Caspases are crucial mediators of programmed cell death (apoptosis). Among them, caspase-3 is a frequently activated death… (More)
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Highly Cited
1999
Highly Cited
1999
Exit of cytochrome c from mitochondria into the cytosol has been implicated as an important step in apoptosis. In the cytosol… (More)
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Highly Cited
1998
Highly Cited
1998
Interleukin 1beta-converting enzyme-like proteases (caspases) are crucial components of cell death pathways. Among the caspases… (More)
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Highly Cited
1998
Highly Cited
1998
Inhibitor of apoptosis (IAP) gene products play an evolutionarily conserved role in regulating programmed cell death in diverse… (More)
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Highly Cited
1997
Highly Cited
1997
We report here the purification of the third protein factor, Apaf-3, that participates in caspase-3 activation in vitro. Apaf-3… (More)
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Highly Cited
1997
Highly Cited
1997
We report here the purification and cDNA cloning of Apaf-1, a novel 130 kd protein from HeLa cell cytosol that participates in… (More)
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Review
1997
Review
1997
Apoptosis is a major form of cell death, characterized initially by a series of stereotypic morphological changes. In the… (More)
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Highly Cited
1997
Highly Cited
1997
We have identified and purified from HeLa cytosol a protein that induces DNA fragmentation in coincubated nuclei after it is… (More)
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Highly Cited
1997
Highly Cited
1997
The caspase-3 (CPP32, apopain, YAMA) family of cysteinyl proteases has been implicated as key mediators of apoptosis in mammalian… (More)
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