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Caspases are crucial mediators of programmed cell death (apoptosis). Among them, caspase-3 is a frequently activated death… Expand Caspase activation plays a central role in the execution of apoptosis. The key components of the biochemical pathways of caspase… Expand Exit of cytochrome c from mitochondria into the cytosol has been implicated as an important step in apoptosis. In the cytosol… Expand Interleukin 1β-converting enzyme-like proteases (caspases) are crucial components of cell death pathways. Among the caspases… Expand Apoptosis is a major form of cell death, characterized initially by a series of stereotypic morphological changes. In the… Expand We report here the purification of the third protein factor, Apaf-3, that participates in caspase-3 activation in vitro. Apaf-3… Expand We report here the purification and cDNA cloning of Apaf-1, a novel 130 kd protein from HeLa cell cytosol that participates in… Expand We have identified and purified from HeLa cytosol a protein that induces DNA fragmentation in coincubated nuclei after it is… Expand The caspase-3 (CPP32, apopain, YAMA) family of cysteinyl proteases has been implicated as key mediators of apoptosis in mammalian… Expand The protease responsible for the cleavage of poly(ADP-ribose) polymerase and necessary for apoptosis has been purified and… Expand