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LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity.
TLDR
The results of the present study suggest that moesin, ezrin and radixin may be LRRK2 substrates, findings that have been exploited to develop the first robust quantitative assay to measure L RRK2 kinase activity.
Leucine‐rich repeat kinase 2 phosphorylates brain tubulin‐beta isoforms and modulates microtubule stability – a point of convergence in Parkinsonian neurodegeneration?
  • F. Gillardon
  • Biology, Chemistry
    Journal of neurochemistry
  • 1 September 2009
TLDR
It is shown that recombinant human LRRK2 preferentially phosphorylates tubulin‐beta purified from bovine brain and that phosphorylation is three‐fold enhanced by the L RRK2(G2019S) mutation, suggesting that LRRk2 (G 2019S)‐induced neurodegeneration in Parkinsonian brains may be partly mediated by increased phosphorylated of tubulin•beta and constraining of microtubule dynamics.
Block of c‐Fos and JunB Expression by Antisense Oligonucleotides Inhibits Light‐induced‐Phase Shifts of the Mammalian Circadian Clock
TLDR
It is demonstrated for the first time that inducible transcription factors such as c‐Fos and JunB are an essential part of fundamental biological processes in the adult mammalian nervous system, e.g. of light‐induced phase shifts of the circadian pacemaker.
Proteomic and functional alterations in brain mitochondria from Tg2576 mice occur before amyloid plaque deposition
TLDR
Altered alterations in the mitochondrial proteome and function that occur in Tg2576 mice brains before amyloid plaque deposition are demonstrated suggesting that mitochondria are early targets of amyloids‐beta aggregates.
Cerebrospinal fluid proteome profile in multiple sclerosis
TLDR
Though the pathophysiological role of these proteins still remains to be elucidated in detail and further validation is needed, these findings may have a relevant impact on the identification of disease-specific markers.
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