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carboxyamido-triazole

Known as: Carboxyaminoimidazole, Carboxyamidotriazole, 4-CAI 
An orally-active agent with potential antineoplastic activity. Carboxyamidotriazole binds to and inhibits non-voltage-operated Ca2+ channels… 
National Institutes of Health

Related topics

Related topics

12 relations

Broader (4)

Aminoimidazole CarboxamideAntineoplastic AgentsCalcium Channel BlockersTriazoles
Angiogenesis InhibitionCalcium Channel InhibitionEndothelial CellsEndothelium, Vascular

Narrower (1)

L 651582

Papers overview

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Highly Cited
2015
Highly Cited
2015
Catalytic oxygenation of sp3 "C-H" bonds with Ir(III) complexes of chelating triazoles and mesoionic carbenes.
Cp*-Ir(III) complexes with additional chelating ligands are known active pre-catalysts for the oxygenation of C-H bonds. We… 
Highly Cited
2012
Highly Cited
2012
Non-HLA antibodies to immunogenic epitopes predict the evolution of chronic renal allograft injury.
Chronic allograft injury (CAI) results from a humoral response to mismatches in immunogenic epitopes between the donor and… 
Highly Cited
2006
Highly Cited
2006
Comparative in vivo activity of BAL4815, the active component of the prodrug BAL8557, in a neutropenic murine model of disseminated Aspergillus flavus.
BACKGROUND BAL8557 (WSA) is the water-soluble prodrug of the triazole BAL4815 with in vitro anti-Aspergillus activity. We… 
2001
2001
Vascular endothelial growth factor-A activates Ca2+ -activated K+ channels in human endothelial cells in culture.
Highly Cited
2000
Highly Cited
2000
CAIR-1/BAG-3 forms an EGF-regulated ternary complex with phospholipase C-gamma and Hsp70/Hsc70.
CAIR-1/BAG-3 forms an EGF-regulated ternary complex with Hsp70/Hsc70 and latent phospholipase C-gamma (PLC-gamma). The expression… 
1999
1999
In vitro antifungal activity of BMS-207147 and itraconazole against yeast strains that are non-susceptible to fluconazole.
Highly Cited
1994
Highly Cited
1994
Structure-function analysis of signal and growth inhibition by carboxyamido-triazole, CAI.
Evidence is accumulating that calcium homeostasis and calcium-regulated events may be selectively important in generation and… 
Highly Cited
1993
Highly Cited
1993
The protective effect of heat stress against reperfusion arrhythmias in the rat.
Heat stress provides protection against mechanical dysfunction and myocardial necrosis after prolonged ischemia. We have… 
1993
1993
Heat stress attenuates free radical release in the isolated perfused rat heart.
1987
1987
Recognition of ovarian cancer antigen CA125 by murine monoclonal antibody produced by immunization of lung cancer cells.
In studies aimed at developing monoclonal antibodies against lung adenocarcinomas, we produced a murine monoclonal antibody… 
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