Structure-function analysis of signal and growth inhibition by carboxyamido-triazole, CAI.

@article{Kohn1994StructurefunctionAO,
  title={Structure-function analysis of signal and growth inhibition by carboxyamido-triazole, CAI.},
  author={Elise C. Kohn and Christian C. Felder and W Jacobs and Kelly A. Holmes and Alan Day and Richard J. Freer and Lance A. Liotta},
  journal={Cancer research},
  year={1994},
  volume={54 4},
  pages={
          935-42
        }
}
Evidence is accumulating that calcium homeostasis and calcium-regulated events may be selectively important in generation and maintenance of the malignant phenotype. CAI, a carboxyamido-triazole with a halogenated benzophenone tail, is a novel inhibitor of receptor-operated calcium influx and arachidonic acid release which inhibits malignant proliferation, invasion, and metastasis. The focus of this investigation was structural analysis of CAI and to determine if the inhibition of calcium… CONTINUE READING

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