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Aminoimidazole Carboxamide

Known as: 1H-Imidazole-4-carboxamide, 5-amino-, Aminoimidazole Carboxamide [Chemical/Ingredient], Carboxamide, Aminoimidazole 
An imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a… Expand
National Institutes of Health

Related topics

Related topics

20 relations

Narrower (13)

2-phenyl-4-amino-5-imidazolecarboxamide5-aminoimidazole-4-carboxamide-1-ribofuranosyl triphosphate5-thiobredininAICA ribonucleotide
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In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Regulatory mode shift of Tbc1d1 is required for acquisition of insulin-responsive GLUT4-trafficking activity
Tbc1d1 is involved in AICAR-dependent GLUT4 liberation. Tbc1d1 acquires temporal insulin responsiveness with AICAR pretreatment… Expand
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2013
2013
The effects of chronic AMPK activation on hepatic triglyceride accumulation and glycerol 3-phosphate acyltransferase activity with high fat feeding
BackgroundHigh fat feeding increases hepatic fat accumulation and is associated with hepatic insulin resistance. AMP Activated… Expand
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Highly Cited
2012
Highly Cited
2012
Palmitate causes endoplasmic reticulum stress and apoptosis in human mesenchymal stem cells: prevention by AMPK activator.
Elevated circulating saturated fatty acids concentration is commonly associated with poorly controlled diabetes. The highly… Expand
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Highly Cited
2011
Highly Cited
2011
Phosphorylation of the insulin receptor by AMP-activated protein kinase (AMPK) promotes ligand-independent activation of the insulin signalling pathway in rodent muscle
Aims/hypothesisMuscle may experience hypoglycaemia during ischaemia or insulin infusion. During severe hypoglycaemia energy… Expand
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2006
2006
Inhibition of Fructose-1,6-bisphosphatase by Aminoimidazole Carboxamide Ribotide Prevents Growth of Salmonella enterica purH Mutants on Glycerol*
The enzyme fructose-1,6-bisphosphatase (FBP) is key regulatory point in gluconeogenesis. Mutants of Salmonella enterica lacking… Expand
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Highly Cited
1999
Highly Cited
1999
Metabolic activation of dacarbazine by human cytochromes P450: the role of CYP1A1, CYP1A2, and CYP2E1.
Dacarbazine (DTIC), a widely used anticancer agent, is inactive until metabolized in the liver by cytochromes P450 to form the… Expand
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1998
1998
The effect of methotrexate and 7-hydroxymethotrexate on rat adjuvant arthritis and on urinary aminoimidazole carboxamide excretion.
OBJECTIVE To study the efficacy, toxicity, and antifolate activities of 7-hydroxymethotrexate (7-OH-MTX) versus methotrexate (MTX… Expand
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1993
1993
Synthesis and structure-activity relationships of new cephalosporins with aminoimidazoles at C-7. Effect of the pKa of the C-7 aminoimidazole on antibacterial spectrum and beta-lactamase stability.
Cephalosporins with new aminoimidazole heterocycles at C-7 have been synthesized by reaction of anti-alpha-aminooximes with C-7… Expand
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1989
1989
Methenyltetrahydrofolate synthetase prevents the inhibition of phosphoribosyl 5-aminoimidazole 4-carboxamide ribonucleotide formyltransferase by 5-formyltetrahydrofolate polyglutamates.
Methenyltetrahydrofolate synthetase (EC 6.3.3.2) catalyzes the irreversible ATP and Mg2+-dependent transformation of 5… Expand
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Highly Cited
1988
Highly Cited
1988
The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase…
A nitroreductase enzyme has been isolated from Walker 256 rat carcinoma cells which can convert 5-(aziridin-1-yl)-2,4… Expand
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