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Aminoimidazole Carboxamide

Known as: 1H-Imidazole-4-carboxamide, 5-amino-, Aminoimidazole Carboxamide [Chemical/Ingredient], Carboxamide, Aminoimidazole 
An imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a… 
National Institutes of Health

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Narrower (13)

2-phenyl-4-amino-5-imidazolecarboxamide5-aminoimidazole-4-carboxamide-1-ribofuranosyl triphosphate5-thiobredininAICA ribonucleotide
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

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2015
2015
LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia.
2013
2013
Regulatory mode shift of Tbc1d1 is required for acquisition of insulin-responsive GLUT4-trafficking activity
Tbc1d1 is involved in AICAR-dependent GLUT4 liberation. Tbc1d1 acquires temporal insulin responsiveness with AICAR pretreatment… 
2012
2012
Sustained activation of AMPK ameliorates age-associated vascular endothelial dysfunction via a nitric oxide-independent mechanism
Highly Cited
2012
Highly Cited
2012
Phosphorylation of the insulin receptor by AMP-activated protein kinase (AMPK) promotes ligand-independent activation of the insulin signalling pathway in rodent muscle
Aims/hypothesisMuscle may experience hypoglycaemia during ischaemia or insulin infusion. During severe hypoglycaemia energy… 
Highly Cited
2012
Highly Cited
2012
Palmitate causes endoplasmic reticulum stress and apoptosis in human mesenchymal stem cells: prevention by AMPK activator.
Elevated circulating saturated fatty acids concentration is commonly associated with poorly controlled diabetes. The highly… 
2006
2006
Inhibition of Fructose-1,6-bisphosphatase by Aminoimidazole Carboxamide Ribotide Prevents Growth of Salmonella enterica purH Mutants on Glycerol*
The enzyme fructose-1,6-bisphosphatase (FBP) is key regulatory point in gluconeogenesis. Mutants of Salmonella enterica lacking… 
Highly Cited
1999
Highly Cited
1999
Metabolic activation of dacarbazine by human cytochromes P450: the role of CYP1A1, CYP1A2, and CYP2E1.
Dacarbazine (DTIC), a widely used anticancer agent, is inactive until metabolized in the liver by cytochromes P450 to form the… 
1998
1998
The effect of methotrexate and 7-hydroxymethotrexate on rat adjuvant arthritis and on urinary aminoimidazole carboxamide excretion.
OBJECTIVE To study the efficacy, toxicity, and antifolate activities of 7-hydroxymethotrexate (7-OH-MTX) versus methotrexate (MTX… 
Highly Cited
1988
Highly Cited
1988
The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase…
1974
1974
Folic acid non-dependent formiminoglutamic aciduria in two siblings.
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