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Aminoimidazole Carboxamide
Known as:
1H-Imidazole-4-carboxamide, 5-amino-
, Aminoimidazole Carboxamide [Chemical/Ingredient]
, Carboxamide, Aminoimidazole
An imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a…
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National Institutes of Health
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Related topics
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20 relations
Narrower (13)
2-phenyl-4-amino-5-imidazolecarboxamide
5-aminoimidazole-4-carboxamide-1-ribofuranosyl triphosphate
5-thiobredinin
AICA ribonucleotide
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In Blood
agonists
analogs & derivatives
antagonists & inhibitors
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia.
Gao Sun
,
G. da Silva Xavier
,
+13 authors
G. Rutter
Molecular Metabolism
2015
Corpus ID: 13951274
2013
2013
Regulatory mode shift of Tbc1d1 is required for acquisition of insulin-responsive GLUT4-trafficking activity
Hiroyasu Hatakeyama
,
M. Kanzaki
Molecular Biology of the Cell
2013
Corpus ID: 14466378
Tbc1d1 is involved in AICAR-dependent GLUT4 liberation. Tbc1d1 acquires temporal insulin responsiveness with AICAR pretreatment…
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2012
2012
Sustained activation of AMPK ameliorates age-associated vascular endothelial dysfunction via a nitric oxide-independent mechanism
L. Lesniewski
,
Melanie C. Zigler
,
J. Durrant
,
A. Donato
,
D. Seals
Mechanisms of Ageing and Development
2012
Corpus ID: 39184896
Highly Cited
2012
Highly Cited
2012
Phosphorylation of the insulin receptor by AMP-activated protein kinase (AMPK) promotes ligand-independent activation of the insulin signalling pathway in rodent muscle
I. Chopra
,
H. F. Li
,
H. Wang
,
K. Webster
Diabetologia
2012
Corpus ID: 206872729
Aims/hypothesisMuscle may experience hypoglycaemia during ischaemia or insulin infusion. During severe hypoglycaemia energy…
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Highly Cited
2012
Highly Cited
2012
Palmitate causes endoplasmic reticulum stress and apoptosis in human mesenchymal stem cells: prevention by AMPK activator.
Jun Lu
,
Qinghua Wang
,
+5 authors
Jian-ming Tan
Endocrinology
2012
Corpus ID: 207064781
Elevated circulating saturated fatty acids concentration is commonly associated with poorly controlled diabetes. The highly…
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2006
2006
Inhibition of Fructose-1,6-bisphosphatase by Aminoimidazole Carboxamide Ribotide Prevents Growth of Salmonella enterica purH Mutants on Glycerol*
Michael J. Dougherty
,
J. Boyd
,
D. Downs
Journal of Biological Chemistry
2006
Corpus ID: 15505195
The enzyme fructose-1,6-bisphosphatase (FBP) is key regulatory point in gluconeogenesis. Mutants of Salmonella enterica lacking…
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Highly Cited
1999
Highly Cited
1999
Metabolic activation of dacarbazine by human cytochromes P450: the role of CYP1A1, CYP1A2, and CYP2E1.
J. Reid
,
M. Kuffel
,
J. Miller
,
R. Rios
,
M. Ames
Clinical Cancer Research
1999
Corpus ID: 182929
Dacarbazine (DTIC), a widely used anticancer agent, is inactive until metabolized in the liver by cytochromes P450 to form the…
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1998
1998
The effect of methotrexate and 7-hydroxymethotrexate on rat adjuvant arthritis and on urinary aminoimidazole carboxamide excretion.
J. Baggott
,
S. Morgan
,
W. Koopman
Arthritis & Rheumatism
1998
Corpus ID: 11038620
OBJECTIVE To study the efficacy, toxicity, and antifolate activities of 7-hydroxymethotrexate (7-OH-MTX) versus methotrexate (MTX…
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Highly Cited
1988
Highly Cited
1988
The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase…
R. Knox
,
M. Boland
,
F. Friedlos
,
B. Coles
,
C. Southan
,
J. Roberts
Biochemical Pharmacology
1988
Corpus ID: 9747474
1974
1974
Folic acid non-dependent formiminoglutamic aciduria in two siblings.
A. Niederwieser
,
P. Giliberti
,
A. Matasović
,
S. Pluznik
,
B. Steinmann
,
K. Baerlocher
Clinica chimica acta; international journal of…
1974
Corpus ID: 25156494
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