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Ghrelin is involved in the regulation of somatic growth, feeding behavior and energy homeostasis. Ghrelin stimulates neuropeptide… Expand Tbc1d1 is involved in AICAR-dependent GLUT4 liberation. Tbc1d1 acquires temporal insulin responsiveness with AICAR pretreatment… Expand BackgroundHigh fat feeding increases hepatic fat accumulation and is associated with hepatic insulin resistance. AMP Activated… Expand Elevated circulating saturated fatty acids concentration is commonly associated with poorly controlled diabetes. The highly… Expand Aims/hypothesisMuscle may experience hypoglycaemia during ischaemia or insulin infusion. During severe hypoglycaemia energy… Expand The enzyme fructose-1,6-bisphosphatase (FBP) is key regulatory point in gluconeogenesis. Mutants of Salmonella enterica lacking… Expand Dacarbazine (DTIC), a widely used anticancer agent, is inactive until metabolized in the liver by cytochromes P450 to form the… Expand OBJECTIVE
To study the efficacy, toxicity, and antifolate activities of 7-hydroxymethotrexate (7-OH-MTX) versus methotrexate (MTX… Expand Methenyltetrahydrofolate synthetase (EC 18.104.22.168) catalyzes the irreversible ATP and Mg2+-dependent transformation of 5… Expand A nitroreductase enzyme has been isolated from Walker 256 rat carcinoma cells which can convert 5-(aziridin-1-yl)-2,4… Expand