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Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse.
To evaluate the role of oncogenic RAS mutations in pancreatic tumorigenesis, we directed endogenous expression of KRAS(G12D) to progenitor cells of the mouse pancreas. We find that physiologicalExpand
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Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation
Lance A. Liotta, Patricia S. Steeg, and William G. Stetler-Stevenson Laboratory of Pathology National Cancer Institute National Institutes of Health Bethesda, Maryland 20892 The most life-threateningExpand
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Use of proteomic patterns in serum to identify ovarian Cancer
In this study, a new high-order bioinformatics tool used to identify differences in proteomic patterns in serum was evaluated for its ability to detect the presence of cancer in the ovary. TheExpand
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Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.
Transforming growth factor type beta (TGF-beta), when injected subcutaneously in newborn mice, causes formation of granulation tissue (induction of angiogenesis and activation of fibroblasts toExpand
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Use of proteomic patterns in serum to identify ovarian cancer
BACKGROUND New technologies for the detection of early-stage ovarian cancer are urgently needed. Pathological changes within an organ might be reflected in proteomic patterns in serum. We developed aExpand
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Laser capture microdissection.
Laser capture microdissection (LCM) under direct microscopic visualization permits rapid one-step procurement of selected human cell populations from a section of complex, heterogeneous tissue. InExpand
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered theExpand
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Positional cloning of the gene for multiple endocrine neoplasia-type 1.
Multiple endocrine neoplasia-type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized by tumors in parathyroids, enteropancreatic endocrine tissues, and the anterior pituitary.Expand
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The microenvironment of the tumour–host interface
Throughout the entire process of cancer aetiology, progression and metastasis, the microenvironment of the local host tissue can be an active participant. Invasion occurs within a tumour–hostExpand
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Laser-capture microdissection
Deciphering the cellular and molecular interactions that drive disease within the tissue microenvironment holds promise for discovering drug targets of the future. In order to recapitulate the inExpand
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