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The best understood system for the transport of macromolecules between the cytoplasm and the nucleus is the classical nuclear… Expand Karyopherinbeta (Kapbeta) proteins bind nuclear localization and export signals (NLSs and NESs) to mediate nucleocytoplasmic… Expand Noncoding RNA molecules (ncRNAs) have been implicated in numerous biological processes including transcriptional regulation and… Expand In addition to their roles in IGF transport, the six IGF-binding proteins (IGFBPs) regulate cell activity in various ways. By… Expand Proteins of the karyopherin alpha and karyopherin beta families play a central role in nucleocytoplasmic transport. Recently… Expand The compartmentation of eukaryotic cells requires all nuclear proteins to be imported from the cytoplasm, whereas, for example… Expand Nuclear protein export is mediated by nuclear export signals (NESs), but the mechanisms governing this transport process are not… Expand The GTPase Ran is essential for nuclear import of proteins with a classical nuclear localization signal (NLS). Ran's nucleotide… Expand Targeting of most nuclear proteins to the cell nucleus is initiated by interaction between the classical nuclear localization… Expand The importin‐alpha/beta heterodimer and the GTPase Ran play key roles in nuclear protein import. Importin binds the nuclear… Expand