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Herpesviruses are large DNA viruses which depend on many nuclear functions, and therefore on host transport factors to ensure… Expand The Hippo signaling pathway controls organ size by orchestrating cell proliferation and apoptosis. When the Hippo pathway was… Expand Importin α1 is involved in nuclear import as a receptor for proteins with a classical nuclear localization signal (cNLS). Here… Expand Epidemiological and experimental studies have shown that high-risk human papillomaviruses (HPVs) are the causative agents of… Expand 26 S proteasomes fulfill final steps in the ubiquitin-dependent degradation pathway by recognizing and hydrolyzing ubiquitylated… Expand ABSTRACT To further our understanding of how the nucleocytoplasmic transport machinery interfaces with its cargoes and how this… Expand Abstract. Human karyopherin α2 (KPNA2), a member of the karyopherin α family, plays a key role in the nuclear import of proteins… Expand The vertebrate nuclear pore complex (NPC) harbors an ∼10-nm diameter diffusion channel that is large enough to admit 50-kD… Expand ABSTRACT It has been suggested that nonstructural protein 5A (NS5A) of hepatitis C virus (HCV) plays a role in the incapacitation… Expand Nuclear import of classical nuclear localization sequence-bearing proteins is mediated by karyopherin alpha/beta1 heterodimers. A… Expand