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Transport between the cell nucleus and the cytoplasm.
The compartmentation of eukaryotic cells requires all nuclear proteins to be imported from the cytoplasm, whereas, for example, transfer RNAs, messenger RNAs, and ribosomes are made in the nucleus… Expand
Nuclear Export of MicroRNA Precursors
MicroRNAs (miRNAs), which function as regulators of gene expression in eukaryotes, are processed from larger transcripts by sequential action of nuclear and cytoplasmic ribonuclease III–like… Expand
Identification of different roles for RanGDP and RanGTP in nuclear protein import.
The importin‐alpha/beta heterodimer and the GTPase Ran play key roles in nuclear protein import. Importin binds the nuclear localization signal (NLS). Translocation of the resulting import ligand… Expand
The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleus
- E. Izaurralde, U. Kutay, C. von Kobbe, I. Mattaj, D. Görlich
- Medicine, Biology
- The EMBO journal
- 3 November 1997
The GTPase Ran is essential for nuclear import of proteins with a classical nuclear localization signal (NLS). Ran's nucleotide‐bound state is determined by the chromatin‐bound exchange factor RCC1… Expand
A Novel Class of RanGTP Binding Proteins
- D. Görlich, M. Dabrowski, +5 authors E. Izaurralde
- Biology, Medicine
- The Journal of cell biology
- 14 July 1997
The importin-α/β complex and the GTPase Ran mediate nuclear import of proteins with a classical nuclear localization signal. Although Ran has been implicated also in a variety of other processes,… Expand
LINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN Proteins
Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the nuclear envelope and are composed of KASH and SUN proteins residing in the outer and inner nuclear membrane, respectively. LINC… Expand
Nucleocytoplasmic transport: taking an inventory
In eukaryotic cells, the enclosure of the genetic information in the nucleus allows the spatial and temporal separation of DNA replication and transcription from cytoplasmic protein synthesis. This… Expand
Leucine-rich nuclear-export signals: born to be weak.
CRM1 mediates the nuclear export of proteins exposing leucine-rich nuclear-export signals (NESs). Most NESs bind to CRM1 with relatively low affinity. Recently, higher-affinity NESs were selected… Expand
Export of importin alpha from the nucleus is mediated by a specific nuclear transport factor.
NLS proteins are transported into the nucleus by the importin alpha/beta heterodimer. Importin alpha binds the NLS, while importin beta mediates translocation through the nuclear pore complex. After… Expand
Protein transport across the eukaryotic endoplasmic reticulum and bacterial inner membranes.
Protein transport across the endoplasmic reticulum membrane can occur by two pathways, a co- and a post-translational one. In both cases, polypeptides are first targeted to translocation sites in the… Expand