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Opposing effects of 60% oxygen and neutrophil influx on alveologenesis in the neonatal rat.
The lungs of newborn rats exposed to 60% oxygen for 14 days develop an injury that shares morphologic similarities to human bronchopulmonary dysplasia (BPD). Neutrophil influx into the lung, as partExpand
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Lung inflammation as a therapeutic target in cystic fibrosis.
Cystic fibrosis (CF) lung disease is characterized by chronic neutrophilic inflammation and infection. Effective management of airway inflammation could complement other therapies for the treatmentExpand
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Female gender hormones regulate mRNA levels and function of the rat lung epithelial Na channel.
The epithelial Na channel (ENaC) plays a critical role in the active reabsorption of alveolar fluid at the time of birth or during pulmonary edema. Although rat (r) ENaC is regulated byExpand
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Bronchial artery embolization for severe hemoptysis in cystic fibrosis.
We studied the long-term outcome after BAE for life-threatening hemoptysis in patients with CF. Data from pulmonary function tests were available for 18 of the 25 patients followed. A case-controlExpand
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Coordination of growth and differentiation in the fetal lung.
The male fetal lung begins to synthesize surfactant later in gestation than the female. This delay appears to be caused by androgens. We hypothesized that male fetal lung differentiation is delayedExpand
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Estrogen aggravates inflammation in Pseudomonas aeruginosa pneumonia in cystic fibrosis mice
BackgroundAmong patients with cystic fibrosis (CF), females have worse pulmonary function and survival than males, primarily due to chronic lung inflammation and infection with Pseudomonas aeruginosaExpand
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Glucose intolerance in children with cystic fibrosis.
OBJECTIVE To evaluate the relations among glucose intolerance, genotype, and exocrine pancreatic status in patients with cystic fibrosis (CF). STUDY DESIGN Data on 335 patients <18 years of ageExpand
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The growth factor midkine is modulated by both glucocorticoid and retinoid in fetal lung development.
The glucocorticoids (GC) and retinoids (RA) modulate branching morphogenesis and cytodifferentiation in the developing lung. We investigated downstream target genes that link glucocorticoidExpand
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JNK Activation Turns on LPS- and Gram-Negative Bacteria-Induced NADPH Oxidase-Dependent Suicidal NETosis
Neutrophils cast neutrophil extracellular traps (NETs) to ensnare microbial pathogens. Nevertheless, the molecular rheostats that regulate NETosis in response to bacteria are not clearly established.Expand
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Regulating NETosis: Increasing pH Promotes NADPH Oxidase-Dependent NETosis
Neutrophils migrating from the blood (pH 7.35–7.45) into the surrounding tissues encounter changes in extracellular pH (pHe) conditions. Upon activation of NADPH oxidase 2 (Nox), neutrophils generateExpand
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