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belinostat

Known as: 2-Propenamide, N-hydroxy-3-(3-((phenylamino)sulfonyl)phenyl)- 
A novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibiting… 
National Institutes of Health

Related topics

Related topics

11 relations
Angiogenesis InhibitionHistone DeacetylaseNCIt Antineoplastic Agent TerminologyPositive Regulation of Apoptosis

Broader (4)

Antineoplastic AgentsHistone deacetylase inhibitorHydroxamic AcidsSulfonamides

Narrower (1)

PXD101

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
Histone Deacetylase Inhibitors in Pediatric Brain Cancers: Biological Activities and Therapeutic Potential
Brain cancers are the leading cause of cancer-related deaths in children. Biological changes in these tumors likely include… 
Review
2017
Review
2017
Novel Agents in the Treatment of Relapsed or Refractory Peripheral T-Cell Lymphoma.
2015
2015
Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).
2015
2015
Safe and Effective Treatment of Patients with Peripheral T-Cell Lymphoma (PTCL) with the Novel HDAC Inhibitor, Belinostat, in Combination with CHOP: Results of the Bel-CHOP Phase 1 Trial
Background: Peripheral T-cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin lymphomas associated with poor prognosis… 
2015
2015
PXD101 significantly improves nuclear reprogramming and the in vitro developmental competence of porcine SCNT embryos.
Review
2015
Review
2015
Targeting New Candidate Genes by Small Molecules Approaching Neurodegenerative Diseases
Neurodegenerative diseases (NDs) are among the most feared of the disorders that afflict humankind for the lack of specific… 
2011
2011
Histone Deacetylase Inhibitor Belinostat Represses Survivin Expression through Reactivation of Transforming Growth Factor β (TGFβ) Receptor II Leading to Cancer Cell Death*
Survivin is a cancer-associated gene that functions to promote cell survival, cell division, and angiogenesis and is a marker of… 
2009
2009
Gene expression-signature of belinostat in cell lines is specific for histone deacetylase inhibitor treatment, with a corresponding signature in xenografts
Belinostat is a hydroxamate-type histone deactylase inhibitor (HDACi), which has recently entered phase I and II clinical trials… 
2008
2008
Plasma and cerebrospinal fluid pharmacokinetics of the histone deacetylase inhibitor, belinostat (PXD101), in non-human primates
PurposeHistone deacetylases (HDAC) are involved in the regulation of gene transcription. Aberrant HDAC activity has been… 
2008
2008
Monitoring the effect of belinostat in solid tumors by H4 acetylation
Histone deacetylase (HDAC) inhibition is a novel entity in medical oncology, and several HDAC inhibitors are in clinical trials… 
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