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asulacrine

Known as: 4-Acridinecarboxamide,9-((2-methoxy-4-((methylsulfonyl)amino)phenyl)amino)-N,5-dimethyl, 4-Acridinecarboxamide,9-((2-methoxy-4-((methylsulfonyl)amino)phenyl)amino-N,5-dimethyl, N-5-dimethyl-9-((2-methoxy-4-methylsulfonylamino)phenylamino)-4-acridinecarboxamide 
An amsacrine analogue with antineoplastic properties. Asulacrine inhibits the enzyme topoisomerase ll, thereby blocking DNA replication and RNA and… 
National Institutes of Health

Related topics

Related topics

7 relations

Broader (3)

AmsacrineAntineoplastic AgentsTopoisomerase II Inhibitors

Narrower (2)

AmsalogCI 921
NCIt Antineoplastic Agent Terminologyanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Fast Monte Carlo based joint iterative reconstruction for simultaneous Tc99m∕I123 SPECT imaging.
Simultaneous Tc99m∕I123 SPECT allows the assessment of two physiological functions under identical conditions. The separation of… 
2004
2004
NAD(P)H:Quinone Oxidoreductase-1-Dependent and -Independent Cytotoxicity of Potent Quinone Cdc25 Phosphatase Inhibitors
Cdc25 dual-specificity phosphatases coordinate cell cycle progression and cellular signaling. Consequently, Cdc25 inhibitors… 
2004
2004
Experimental solid tumour activity ofN-[2-(dimethylamino)ethyl]-acridine-4-carboxamide
N-[2-(Dimethylamino)ethyl]acridine-4-carboxamide (DACA), a DNA intercalator that exerts its antitumour action through the enzyme… 
1993
1993
Anticancer drug sensitivity profiles of new and established melanoma cell lines.
Metastatic melanoma is notable for its resistance to chemotherapy, and methods for determining resistance in cultures would be… 
1990
1990
Disposition of amsacrine and its analogue 9-([2-methoxy-4-[(methylsulfonyl)amino]phenyl]amino)-N,5-dimethyl-4- acridinecarboxamide (CI-921) in plasma, liver, and Lewis lung tumors in mice.
9-([2-Methoxy-4-[(methylsulfonyl)amino]phenyl]amino)-N,5-dimethyl-4- acridinecarboxamide (CI-921), an analogue of the clinical… 
1989
1989
Chemoprotection by 9-aminoacridine derivatives against the cytotoxicity of topoisomerase II-directed drugs.
1988
1988
Phase I trial of the amsacrine analogue 9-[( 2-methoxy-4-[(methylsulfonyl)amino]-phenyl]amino)-N,5-dimethyl-4- acridinecarboxamide (CI-921).
CI-921, an analogue of amsacrine with superior activity against in vivo and in vitro experimental tumor models, has been studied… 
1988
1988
Mechanism of resistance of noncycling mammalian cells to 4'-(9-acridinylamino)methanesulfon-m-anisidide: comparison of uptake, metabolism, and DNA breakage in log- and plateau-phase Chinese hamster…
Resistance of noncycling cells to amsacrine (m-AMSA) has been widely reported and may limit the activity of this drug against… 
Highly Cited
1986
Highly Cited
1986
Comparison of in vitro activity of cytotoxic drugs towards human carcinoma and leukaemia cell lines.
1968
1968
Aureolic Acid Group of Anti-tumour Antibiotics
SINCE 1953 several antibiotics of similar biological and physico-chemical properties have been described. These are aureolic… 
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