CI 921

Known as: CI-921 
A synthetic derivative of acridine carboxamide with antineoplastic properties. CI-921, a lipophilic and water-soluble analog of amsacrine, inhibits… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1986-2006
02419862006

Papers overview

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2001
2001
Purpose: Amsalog, a derivative of 9-aminoacridine, is an inhibitor of topoisomerase II. Early studies of intravenous amsalog… (More)
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1996
1996
CI-921, the 5-methyl-4-carboxamide analog of amsacrine, in combination with cisplatin produced a 6-fold better cell kill in vitro… (More)
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1992
1992
CI-921, (9-[[2-methoxy-4-[(methylsulfonyl)amino]phenyl]amino]-N,5-dimethyl-4-acridinecarboxamide 2-hydroxyethanesulfonate (1∶1… (More)
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1990
1990
The aim was to investigate interspecies relationships between body weight (W) (kg) and various pharmacokinetic parameters for the… (More)
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1990
1990
9-([2-Methoxy-4-[(methylsulfonyl)amino]phenyl]amino)-N,5-dimethyl-4- acridinecarboxamide (CI-921), an analogue of the clinical… (More)
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1988
1988
CI-921, an analogue of amsacrine with superior activity against in vivo and in vitro experimental tumor models, has been studied… (More)
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1988
1988
The pharmacokinetics of CI-921 were studied after 65 infusions over a 20-fold dose range (13–270 mg/m2 per day) in 16 patients… (More)
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1988
1988
The antitumour agent 9-[[2-methoxy-4-[methylsulphonylamino]-phenyl]amino]-N,5-dimethyl- 4-acridinecarboxamide (CI-921; NSC 343499… (More)
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1987
1987
N-5-dimethyl-9-[(2-methoxy-4-methylsulphonylamino)phenylamino]-4-acridinecarboxamide (CI-921), which is an analogue of amsacrine… (More)
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1986
1986
CI-921, a 4,5-disubstituted analog of amsacrine, has been selected for clinical testing because of its experimental activity in… (More)
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