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CI 921

Known as: CI-921 
A synthetic derivative of acridine carboxamide with antineoplastic properties. CI-921, a lipophilic and water-soluble analog of amsacrine, inhibits… 
National Institutes of Health

Related topics

Related topics

2 relations
Amsalog

Broader (1)

asulacrine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2004
2004
Dose-dependent pharmacokinetics of N-5-dimethyl-9-[(2-methoxy-4-methylsulphonylamino)phenylamino]-4-acridinecarboxamide (CI-921) in rabbits
SummaryN-5-dimethyl-9-[(2-methoxy-4-methylsulphonylamino)phenylamino]-4-acridinecarboxamide (CI-921), which is an analogue of… 
2004
2004
The effect of cimetidine, phenobarbitone and buthionine sulphoximine on the disposition of N-5-dimethyl-9-[(2-methoxy-4-methyl-sulphonylamino) phenylamino]-4-acridinecarboxamide (CI-921) in the…
SummaryN-5-dimethyl-9-[(2-methoxy-4-methylsulphonylamino)phenylamino]-4-acridinecarboxamide (CI-921) is an amsacrine analogue… 
2001
2001
A phase I trial of amsalog (CI-921) administered by intravenous infusion using a 5-day schedule
Purpose: Amsalog, a derivative of 9-aminoacridine, is an inhibitor of topoisomerase II. Early studies of intravenous amsalog… 
2001
2001
A study of amsalog (CI-921) administered orally on a 5-day schedule, with bioavailability and pharmacokinetically guided dose escalation
Abstract.Purpose: Amsalog is a derivative of 9-aminoacridine. Phase I studies using intravenous (i.v.) amsalog have shown the… 
1996
1996
Enhanced therapeutic effect of amsalog (CI-921) in combination with cisplatin in vitro and in vivo.
CI-921, the 5-methyl-4-carboxamide analog of amsacrine, in combination with cisplatin produced a 6-fold better cell kill in vitro… 
1992
1992
A phase II trial of CI-921 in advanced malignancies
CI-921, (9-[[2-methoxy-4-[(methylsulfonyl)amino]phenyl]amino]-N,5-dimethyl-4-acridinecarboxamide 2-hydroxyethanesulfonate (1∶1… 
1990
1990
Disposition of amsacrine and its analogue 9-([2-methoxy-4-[(methylsulfonyl)amino]phenyl]amino)-N,5-dimethyl-4- acridinecarboxamide (CI-921) in plasma, liver, and Lewis lung tumors in mice.
9-([2-Methoxy-4-[(methylsulfonyl)amino]phenyl]amino)-N,5-dimethyl-4- acridinecarboxamide (CI-921), an analogue of the clinical… 
1988
1988
Phase I trial of the amsacrine analogue 9-[( 2-methoxy-4-[(methylsulfonyl)amino]-phenyl]amino)-N,5-dimethyl-4- acridinecarboxamide (CI-921).
CI-921, an analogue of amsacrine with superior activity against in vivo and in vitro experimental tumor models, has been studied… 
1988
1988
THIOLYTIC CLEAVAGE AND BINDING OF THE ANTITUMOUR AGENT CI-921 IN BLOOD
The antitumour agent 9-[[2-methoxy-4-[methylsulphonylamino]-phenyl]amino]-N,5-dimethyl- 4-acridinecarboxamide (CI-921; NSC 343499… 
1986
1986
Effects of anthrapyrazole antineoplastic agents on lipid peroxidation.
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