Skip to search formSkip to main contentSkip to account menu

amonafide

Known as: BIDA, 1H-Benz(de)isoquinoline-1,3(2H)-dione, 5-amino-2-(2-(dimethylamino)ethyl)-, Benzisoquinolinedione 
An imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks… 
National Institutes of Health

Related topics

Related topics

8 relations

Broader (5)

Antineoplastic AgentsAntiviral AgentsEnzyme InhibitorsIntercalating Agents

Narrower (2)

NSC 308847amonafide dihydrochloride
amonafide L-malate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Novel thiazonaphthalimides as efficient antitumor and DNA photocleaving agents: effects of intercalation, side chains, and substituent groups.
Highly Cited
2004
Highly Cited
2004
New analogues of amonafide and elinafide, containing aromatic heterocycles: synthesis, antitumor activity, molecular modeling, and DNA binding properties.
Amonafide- and elinafide-related mono and bisintercalators, modified by the introduction of a pi-excedent furan or thiophene ring… 
1999
1999
High‐pressure size exclusion chromatography analysis of dissolved organic matter isolated by tangential‐flow ultrafiltration
A 1,000‐Dalton tangential‐flow ultrafiltration (TFUF) membrane was used to isolate dissolved organic matter (DOM) from several… 
Highly Cited
1995
Highly Cited
1995
Susceptibility to tumors induced by polyoma virus is conferred by an endogenous mouse mammary tumor virus superantigen
A dominant gene carried in certain inbred mouse strains confers susceptibility to tumors induced by polyoma virus. This gene… 
Highly Cited
1993
Highly Cited
1993
Phase I study of amonafide dosing based on acetylator phenotype.
Amonafide is extensively metabolized, including N-acetylation to an active metabolite. Prior studies have demonstrated that… 
1992
1992
Evaluation of Amonafide in Cervical Cancer, Phase II: A SWOG Study
The Southwest Oncology Group conducted a Phase II study of amonafide in patients with metastatic or recurrent squamous cell… 
Highly Cited
1991
Highly Cited
1991
Paradoxical relationship between acetylator phenotype and amonafide toxicity
Patients receiving the investigational antineoplastic agent amonafide underwent prospective determination of acetylator phenotype… 
Highly Cited
1989
Highly Cited
1989
Topoisomerase II-mediated DNA cleavage by amonafide and its structural analogs.
Treatment of SV40-infected monkey cells with amonafide (benzisoquinolinedione), an intercalative antitumor drug, resulted in… 
1989
1989
Phase I clinical investigation of amonafide.
Amonafide (benzisoquinolinedione, NSC 308847) is a new synthetic imide antineoplastic agent with DNA intercalative properties… 
Highly Cited
1988
Highly Cited
1988
Limited sampling models for amonafide (NSC 308847) pharmacokinetics.
The limited sampling model (LSM) offers a means of estimating the area under the concentration-time curve (AUC) from only two… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)