amonafide

Known as: BIDA, 1H-Benz(de)isoquinoline-1,3(2H)-dione, 5-amino-2-(2-(dimethylamino)ethyl)-, Benzisoquinolinedione 
An imide derivative of naphthalic acid. Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1980-2018
051019802018

Papers overview

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2010
2010
BACKGROUND Antibodies to aquaporin-4 (AQP4-Ab) are found in 60-80% of patients with neuromyelitis optica (NMO), a severely… (More)
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Highly Cited
2004
Highly Cited
2004
This paper describes an advanced care and alert portable telemedical monitor (AMON), a wearable medical monitoring and alert… (More)
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2001
2001
Amonafide and irinotecan are anticancer drugs representative of the clinical relevance of N-acetyltransferase (NAT) and uridine… (More)
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1995
1995
PURPOSE To determine if variability in toxicity of amonafide during phase II trials could be correlated with pharmacokinetic… (More)
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1993
1993
Amonafide is extensively metabolized, including N-acetylation to an active metabolite. Prior studies have demonstrated that… (More)
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1991
1991
Patients receiving the investigational antineoplastic agent amonafide underwent prospective determination of acetylator phenotype… (More)
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1989
1989
Amonafide (benzisoquinolinedione, NSC 308847) is a new synthetic imide antineoplastic agent with DNA intercalative properties… (More)
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1989
1989
Treatment of SV40-infected monkey cells with amonafide (benzisoquinolinedione), an intercalative antitumor drug, resulted in… (More)
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1988
1988
The limited sampling model (LSM) offers a means of estimating the area under the concentration-time curve (AUC) from only two… (More)
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1987
1987
Pharmacokinetics and urinary excretion of Amonafide (5-amino-2-[2-(dimethylamine)ethyl]-1H-benz[de]isoquinoline-1,3-(2H)- dione… (More)
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