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aclacinomycin B

Known as: 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-((2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexapyranosyl)oxy)-, methyl ester,(1R-(1-alpha,2-beta,4-beta))-, Aclarubicin B 
An antineoplastic oligosaccharide anthracycline antibiotic isolated from the bacterium Streptomyces galilaeus. Aclacinomycin B intercalates into DNA… Expand
National Institutes of Health

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aclacinomycins

Papers overview

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Review
2001
Review
2001
Recent developments in the field of antitumour anthracyclines.
  • Claude Monneret
  • European journal of medicinal chemistry
  • 2001
    • Corpus ID: 40415573
The anthracycline antibiotics daunorubicin (1) and doxorubicin (2) have been introduced in clinical use for more than 30 years… Expand
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1993
1993
Aclacinomycin A in the treatment of experimental proliferative vitreoretinopathy. Efficacy and toxicity in the rabbit eye.
PURPOSE Aclacinomycin A is an oligosaccharide anthracycline that, by contrast with daunomycin, lacks carcinogenicity. The authors… Expand
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1991
1991
Determination of DNA topoisomerase II activity from L1210 cells--a target for screening antitumor agents.
DNA topoisomerase II was isolated from mouse leukemia L1210 cells and the activity was determined by using P4 phage knotted DNA… Expand
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1990
1990
Phase II trial of 6-diazo-5-oxo-L-norleucine versus aclacinomycin-A in advanced sarcomas and mesotheliomas
SummaryNinety-eight patients with previously-treated advanced soft tissue sarcoma, bone sarcoma, or mesothelioma were randomly… Expand
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1983
1983
Delivery of aclacinomycin A to human glioma cells in vitro by the low-density lipoprotein pathway.
The present study shows that a human malignant glioma cell line (U-251 MG) accumulates and degrades low-density lipoprotein (LDL… Expand
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1983
1983
Phase II trial of aclacinomycin A in acute leukemia and various solid tumors
SummaryAclacinomycin A (ACM) is a new anthracycline antibiotic with a reduced cardiac toxicity in animal models. A phase II study… Expand
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1981
1981
New anthracycline antibiotic aclacinomycin A: experimental studies and correlations with clinical trials.
Aclacinomycin A (ACM-A) is an anthracyclic antibiotic whose structure is represented in Fig. 1. It consists of the tetracyclic… Expand
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1981
1981
Alteration of membrane-associated enzymes in drug-resistant sublines of mouse lymphoblastoma L5178Y cells.
Activities of marker enzymes for various cell components were studied with extracts of adriamycin-, aclacinomycin A- and… Expand
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1980
1980
[Studies on the absorption, excretion and distribution of aclacinomycin A: absorption, excretion and distribution of 14C- or 3H-aclacinomycin A in mice, rats and rabbits (author's transl)].
A new anthracycline antitumor antibiotic, aclacinomycin A, was labeled with 3H uniformly or with 14C simultaneously at the… Expand
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1977
1977
Antitumor activity of new anthracycline antibiotics, aclacinomycin-A and its analogs, and their toxicity.
New anthracycline antibiotics have been isolated from the culture of Streptomyces galilaeus MA144-M1. Among 14 anthracycline… Expand
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