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aclacinomycin B

Known as: 1-Naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-((2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexapyranosyl)oxy)-, methyl ester,(1R-(1-alpha,2-beta,4-beta))-, Aclarubicin B 
An antineoplastic oligosaccharide anthracycline antibiotic isolated from the bacterium Streptomyces galilaeus. Aclacinomycin B intercalates into DNA… Expand
National Institutes of Health

Papers overview

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2004
2004
SummaryNinety-eight patients with previously-treated advanced soft tissue sarcoma, bone sarcoma, or mesothelioma were randomly… Expand
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Review
2001
Review
2001
  • C. Monneret
  • European journal of medicinal chemistry
  • 2001
  • Corpus ID: 40415573
The anthracycline antibiotics daunorubicin (1) and doxorubicin (2) have been introduced in clinical use for more than 30 years… Expand
1993
1993
PURPOSE Aclacinomycin A is an oligosaccharide anthracycline that, by contrast with daunomycin, lacks carcinogenicity. The authors… Expand
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Highly Cited
1983
Highly Cited
1983
The present study shows that a human malignant glioma cell line (U-251 MG) accumulates and degrades low-density lipoprotein (LDL… Expand
1983
1983
Streptomyces galilaeus OBB-111 and its blocked mutant were found to convert aclacinomycin B and related anthracycline glycosides… Expand
  • table 1
1982
1982
Aclacinomycin A (ACM) is a new anthracycline antibiotic that produces substantially less cardiotoxicity in animals than does… Expand
1981
1981
Aclacinomycin A (ACM-A) is an anthracyclic antibiotic whose structure is represented in Fig. 1. It consists of the tetracyclic… Expand
1981
1981
Activities of marker enzymes for various cell components were studied with extracts of adriamycin-, aclacinomycin A- and… Expand
1980
1980
A new anthracycline antitumor antibiotic, aclacinomycin A, was labeled with 3H uniformly or with 14C simultaneously at the… Expand
Highly Cited
1977
Highly Cited
1977
New anthracycline antibiotics have been isolated from the culture of Streptomyces galilaeus MA144-M1. Among 14 anthracycline… Expand
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