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UDP-glucuronosyltransferase activity

Known as: UDPGT activity, GT activity, uridine diphosphoglucuronyltransferase activity 
Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. [EC:2.4.1.17]
National Institutes of Health

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3 relations
Glucuronosyltransferasenegative regulation of glucuronosyltransferase activitypositive regulation of glucuronosyltransferase activity

Papers overview

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Review
2010
Review
2010
Modulation of UDP-glucuronosyltransferase activity by endogenous compounds.
Glucuronidation is one of the major pathways of metabolism of endo- and xenobiotics. UDP-Glucuronosyltransferase (UGT)-catalyzed… 
2007
2007
Glucuronidation of Antiallergic Drug, Tranilast: Identification of Human UDP-Glucuronosyltransferase Isoforms and Effect of Its Phase I Metabolite
Tranilast is an oral antiallergic agent widely used in Japan. Recently, in Western populations, hyperbilirubinemia induced by… 
1996
1996
Evidence for an UDP-glucuronic acid/phenol glucuronide antiport in rat liver microsomal vesicles.
The transport of glucuronides synthesized in the luminal compartment of the endoplasmic reticulum by UDP-glucuronosyltransferase… 
1990
1990
Increased thyroxine turnover after 3,3',4,4',5,5'-hexabromobiphenyl injection and lack of effect on peripheral triiodothyronine production.
Juvenile male Wistar rats were injected i.p. with 0, 20, or 40 mg/kg 3,3',4,4',5,5'-hexabromobiphenyl and blood samples collected… 
1985
1985
Separation, purification, and characterization of digitoxigenin-monodigitoxoside UDP-glucuronosyltransferase activity.
Glucuronidation of digitoxigenin-monodigitoxoside was investigated in liver microsomes from spironolactone-induced male Wistar… 
1982
1982
Maximal biliary secretion of bilirubin in the anaesthetized rat: dependence on UDP-glucuronosyltransferase activity.
1. Hepatic bilirubin UDP-glucuronosyl transferase activity in heterozygous Gunn rats (Jj) was only two-thirds of that in the… 
1979
1979
The interaction of styrene oxide with hepatic cytochrome P-450 in vitro and effects of styrene oxide inhalation on xenobiotic biotransformation in mouse liver and kidney.
1976
1976
Solid-phase synthesis of drug glucuronides by immobilized glucuronosyltransferase.
Rabbit liver glucuronosyltransferase immobilized on beaded agarose has been used to synthesize glucuronic acid conjugates of… 
1973
1973
Induction of an Enzyme in Genetically Deficient Rats after Grafting of Normal Liver
Tissue from normal rat livers was grafted onto the livers of rats that were genetically deficient in bilirubin uridine… 
1973
1973
Regulation of microsomal enzymes by phospholipids. VI. Abnormal enzyme-lipid interactions in liver microsomes from Gunn rats.
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