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UDP-glucuronosyltransferase activity

Known as: UDPGT activity, GT activity, uridine diphosphoglucuronyltransferase activity 
Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. [EC:2.4.1.17]
National Institutes of Health

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3 relations
Glucuronosyltransferasenegative regulation of glucuronosyltransferase activitypositive regulation of glucuronosyltransferase activity

Papers overview

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Highly Cited
2002
Highly Cited
2002
UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term.
The activity, expression and localization of the UDP-glucuronosyltransferases (UGTs) were investigated in human placenta at term… Expand
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Highly Cited
2000
Highly Cited
2000
Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine.
UDP-glucuronosyltransferases (UGTs) convert dietary constituents, drugs, and environmental mutagens to inactive hydrophilic… Expand
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Highly Cited
1999
Highly Cited
1999
UDP-glucuronosyltransferase activity in human liver and colon.
BACKGROUND & AIMS The contribution of glucuronidation toward human drug metabolism is carried out by the Super gene family of UDP… Expand
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Highly Cited
1998
Highly Cited
1998
Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation.
Crigler–Najjar syndrome type I is a recessively inherited disorder characterized by severe unconjugated hyperbilirubinemia… Expand
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1998
1998
Increased UDP-glucuronosyltransferase activity and decreased prostate specific antigen production by biochanin A in prostate cancer cells.
Our laboratory has characterized androgen metabolism in an androgen-responsive prostate cancer cell line (LNCaP) and showed that… Expand
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1992
1992
Rat liver microsomal UDP-glucuronosyltransferase activity toward thyroxine: characterization, induction, and form specificity.
Glucuronidation of thyroxine (T4) by liver microsomal UDP-glucuronosyltransferase (UDP-GT) is a predominant pathway by which T4… Expand
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1989
1989
Human liver cell transplantation. Prolonged function in athymic-Gunn and athymic-analbuminemic hybrid rats.
Isolated cryopreserved human liver cells, attached to collagen-coated microcarriers, were injected intraperitoneally into mutant… Expand
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Highly Cited
1986
Highly Cited
1986
Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes.
Isolated hepatocytes, harvested from normal rat livers by portal vein collagenase perfusion, can be attached to collagen-coated… Expand
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1984
1984
Influence of sex and sex steroids on bilirubin uridine diphosphate-glucuronosyltransferase activity of rat liver.
Bilirubin uridine diphosphate-glucuronosyltransferase activity was markedly higher in liver preparations of adult female rats… Expand
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Highly Cited
1979
Highly Cited
1979
Postnatal development of uridine diphosphate glucuronyltransferase activity towards bilirubin and 2-aminophenol in human liver.
UDP-glucuronyltransferase activities towards 2-aminophenol and bilirubin were studied in a total of 70 human subjects, including… Expand
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