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Guidelines for the use and interpretation of assays for monitoring autophagy

These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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Endoplasmic Reticulum Stress

The emerging role of ER stress in diverse human pathophysiological conditions such as carcinogenesis and tumor progression, cerebral ischemia, plasma cell maturation and apoptosis, obesity, insulin resistance, and type 2 diabetes is summarized.
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
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Vitamin C: update on physiology and pharmacology

The increasing knowledge of the functions of ascorbate and of its molecular sites of action can mechanistically substantiate a place for asCorbate in the treatment of various diseases.
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Cooperativity between 11β-Hydroxysteroid Dehydrogenase Type 1 and Hexose-6-phosphate Dehydrogenase in the Lumen of the Endoplasmic Reticulum*

The results demonstrate a close cooperation of the enzymes based on co-localization and the mutual generation of cofactors for each other in rat liver microsomal vesicles.
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The Ascorbate-glutathione-α-tocopherol Triad in Abiotic Stress Response

This work is presenting a review of abiotic stress responses connected to low molecular weight antioxidants, which are capable of chelating metal ions and reducing thus their catalytic activity to form ROS and also scavenge them in plants.
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Ascorbate metabolism and its regulation in animals.

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Preferential Transport of Glutathione versusGlutathione Disulfide in Rat Liver Microsomal Vesicles*

A bi-directional, saturable transport of glutathione (GSH) was found in rat liver microsomal vesicles, and GSSG entrapped and accumulated in the lumen creates the oxidized state of its redox buffer.
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On the role of 4-hydroxynonenal in health and disease.

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mTOR inhibition increases cell viability via autophagy induction during endoplasmic reticulum stress – An experimental and modeling study

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