Glucuronosyltransferase

Known as: UDP Glucuronosyltransferase, Glucuronyl Transferase, UDP, Transferase, Glucuronic 
A family of enzymes accepting a wide range of substrates, including phenols, alcohols, amines, and fatty acids. They function as drug-metabolizing… (More)
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
An exhaustive real-time reverse transcriptase-polymerase chain reaction (PCR) quantification method was used to determine 15 of… (More)
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Review
2005
Review
2005
UDP-glucuronosyltransferase (UGT) enzymes catalyze the conjugation of various endogenous substances (e.g., bilirubin) and… (More)
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Highly Cited
2004
Highly Cited
2004
PURPOSE Severe toxicity is commonly observed in cancer patients receiving irinotecan. UDP-glucuronosyltransferase 1A1 (UGT1A1… (More)
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Review
2004
Review
2004
Glucuronidation is a listed clearance mechanism for 1 in 10 of the top 200 prescribed drugs. The objective of this article is to… (More)
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Highly Cited
2003
Highly Cited
2003
UDP-Glucuronosyltransferases (UGTs) are phase II biotransformation enzymes that glucuronidate numerous endobiotic and xenobiotic… (More)
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Review
2003
Review
2003
In humans, 3beta-hydroxysteroid dehydrogenase (3beta-HSD), 17beta-HSD and 5alpha-reductase activities in androgen target tissues… (More)
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Highly Cited
2001
Highly Cited
2001
The UDP-glucuronosyltransferase, UGT1A1, is the critical enzyme responsible for detoxification of the potentially neurotoxic… (More)
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Highly Cited
1998
Highly Cited
1998
A polymorphism in the promoter of the UDP-glucuronosyltransferase 1 (UGT1A1) gene has been shown to cause Gilbert syndrome, a… (More)
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Highly Cited
1998
Highly Cited
1998
Irinotecan (CPT-11) is a promising antitumor agent, recently approved for use in patients with metastatic colorectal cancer. Its… (More)
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Highly Cited
1998
Highly Cited
1998
Glucuronide conjugation of xenobiotics containing a tertiary amine moiety represents a unique and important metabolic pathway for… (More)
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