Genotoxicity investigations on nanomaterials: methods, preparation and characterization of test material, potential artifacts and limitations--many questions, some answers.
- R. Landsiedel, M. Kapp, M. Schulz, K. Wiench, F. Oesch
- BiologyMutation research
- 1 March 2009
A multiplex polymerase chain reaction protocol for the simultaneous analysis of the glutathione S-transferase GSTM1 and GSTT1 polymorphisms.
- M. Arand, R. Mühlbauer, F. Oesch
- BiologyAnalytical Biochemistry
- 5 April 1996
CRYOPRESERVED PRIMARY HEPATOCYTES AS A CONSTANTLY AVAILABLE IN VITRO MODEL FOR THE EVALUATION OF HUMAN AND ANIMAL DRUG METABOLISM AND ENZYME INDUCTION*
- J. Hengstler, D. Utesch, F. Oesch
- Biology, MedicineDrug metabolism reviews (Softcover ed.)
- 1 January 2000
Cryopreserved hepatocytes held in suspension can be recommended for short-term metabolism or toxicity studies and systems with cryopreservation cultures that could be applied for studies of enzyme induction are already in a state allowing practical application but may be further optimized.
Aryl hydrocarbon receptor activation by cAMP vs. dioxin: divergent signaling pathways.
- B. Oesch-Bartlomowicz, A. Huelster, F. Oesch
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 28 June 2005
It is shown that the second messenger, cAMP (an endogenous mediator of hormones, neurotransmitters, and prostaglandins), activates the AHR, moving the receptor to the nucleus in some ways that are similar to and in other ways fundamentally different from AHR activation by dioxin.
Mammalian epoxide hydrases: inducible enzymes catalysing the inactivation of carcinogenic and cytotoxic metabolites derived from aromatic and olefinic compounds.
- F. Oesch
- Chemistry, BiologyXenobiotica; the fate of foreign compounds in…
- 1 May 1973
Whether a given aromatic or olefinic compound produces such an effect would depend on a variety of factors, such as the relative rate of formation and degradation of the intermediate oxirane, on its stability with respect to spontaneous isomerization to the corresponding phenol and on its chemical electrophilic reactivity.
Occupational exposure to heavy metals: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected.
- J. Hengstler, U. Bolm‐Audorff, F. Oesch
- Environmental ScienceCarcinogenesis
- 2003
The hazard due to cobalt exposure seems to be underestimated, especially when individuals are co-exposed to cadmium or lead, and the existence of more than multiplicative effects for co-exposures of Cadmium, cobalt and lead is found.
The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase
- A. Cronin, S. Mowbray, M. Arand
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 6 February 2003
The mammalian soluble epoxide hydrolase (sEH) is an enzyme with multiple functions, being implicated in detoxification of xenobiotic epoxides as well as in regulation of physiological processes such as blood pressure, and a putative active site containing all necessary components for phosphatase activity is identified.
Carbonyl reductase provides the enzymatic basis of quinone detoxication in man.
- B. Wermuth, K. Platts, A. Seidel, F. Oesch
- Chemistry, BiologyBiochemical Pharmacology
- 15 April 1986
Enhancement of cytotoxicity of artemisinins toward cancer cells by ferrous iron.
- T. Efferth, A. Benakis, M. Marschall
- Biology, ChemistryFree Radical Biology & Medicine
- 1 October 2004
Differential regulation of hepatic glutathione transferase and glutathione peroxidase activities in the rat.
- H. Schramm, L. Robertson, F. Oesch
- BiologyBiochemical Pharmacology
- 15 October 1985
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