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Genotoxicity investigations on nanomaterials: methods, preparation and characterization of test material, potential artifacts and limitations--many questions, some answers.
TLDR
It is concluded that experiences with other, non-nano, substances taught us that mechanisms of genotoxic effects can be diverse and their elucidation can be demanding, while there often is an immediate need to assess the genotoxicity hazard.
The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase
TLDR
The mammalian soluble epoxide hydrolase (sEH) is an enzyme with multiple functions, being implicated in detoxification of xenobiotic epoxides as well as in regulation of physiological processes such as blood pressure, and a putative active site containing all necessary components for phosphatase activity is identified.
Aryl hydrocarbon receptor activation by cAMP vs. dioxin: divergent signaling pathways.
TLDR
It is shown that the second messenger, cAMP (an endogenous mediator of hormones, neurotransmitters, and prostaglandins), activates the AHR, moving the receptor to the nucleus in some ways that are similar to and in other ways fundamentally different from AHR activation by dioxin.
Characterization of cryopreserved rat liver parenchymal cells by metabolism of diagnostic substrates and activities of related enzymes.
TLDR
Cryopreserved, Percoll-purified liver parenchymal cells are a useful in vitro system for drug metabolism studies, however due to the extensive loss in cell number during this procedure the application of this system is limited.
CRYOPRESERVED PRIMARY HEPATOCYTES AS A CONSTANTLY AVAILABLE IN VITRO MODEL FOR THE EVALUATION OF HUMAN AND ANIMAL DRUG METABOLISM AND ENZYME INDUCTION*
TLDR
Cryopreserved hepatocytes held in suspension can be recommended for short-term metabolism or toxicity studies and systems with cryopreservation cultures that could be applied for studies of enzyme induction are already in a state allowing practical application but may be further optimized.
Occupational exposure to heavy metals: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected.
TLDR
The hazard due to cobalt exposure seems to be underestimated, especially when individuals are co-exposed to cadmium or lead, and the existence of more than multiplicative effects for co-exposures of Cadmium, cobalt and lead is found.
Differential regulation of hepatic glutathione transferase and glutathione peroxidase activities in the rat.
TLDR
The inverse regulation of these activities, i.e. the depression of selenium-dependent glutathione peroxidase activity following sustained induction of glutathion transferases, may have direct implications for the toxicity of the polyhalogenated aromatic hydrocarbons.
Characterization of c-kit expression in small cell lung cancer: prognostic and therapeutic implications.
TLDR
c-kit represents a new prognostic factor in SCLC and is of particular clinical relevance in patients with advanced disease and poor response to chemotherapy, given the very limited therapeutic options and unfavorable prognosis of patients.
A method for the cryopreservation of liver parenchymal cells for studies of xenobiotics.
TLDR
An optimized computer-controlled freezing protocol for the cryopreservation of rat liver parenchymal cells was developed and it was found that this protocol was suitable for a variety of liver paretchymic cells from other species when trypan blue exclusion was used as a viability marker.
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