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Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes.
TLDR
A unifying hypothesis is proposed whereby hyperglycemia and FFA-induced activation of the nuclear factor-kappaB, p38 MAPK, and NH2-terminal Jun kinases/stress-activated protein kinases stress pathways plays a key role in causing late complications in type 1 and type 1 diabetes, along with insulin resistance and impaired insulin secretion in type 2 diabetes. Expand
A threshold distribution hypothesis for packet storage of insulin and its mathematical modeling.
  • G. Grodsky
  • Medicine, Chemistry
  • The Journal of clinical investigation
  • 1 August 1972
TLDR
This hypothesis proposes that labile insulin is not stored in a homogeneous form but as packets with a bell-shaped distribution of thresholds to glucose that respond quickly when their threshold levels to glucose are reached or exceeded. Expand
Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?
TLDR
It is proposed here that the hyperglycemia- induced, and possibly FFA-induced, activation of stress pathways plays a key role in the development of not only the late complications in type 1 and type 1 diabetes, but also the insulin resistance and impaired insulin secretion seen in type 2 diabetes. Expand
Effect of age of rat on development of hepatic carriers for bilirubin: a possible explanation for physiologic jaundice and hyperbilirubinemia in the newborn.
TLDR
The immaturity of a carrier system for bilirubin shown in the newborn rat may provide a partial explanation for the physiologic jaundice and hyperbilirubinemia often observed in newborn humans. Expand
Dynamics of insulin secretion by the perfused rat pancreas.
TLDR
The dynamics of insulin release in response to relatively long infusions of glucose were studied in the isolated perfused rat pancreas and Histological examination of the perfused pancreases and measurement of oxygen consumption by these tissues indicated that optimal physiological conditions were used. Expand
Vitamin D deficiency inhibits pancreatic secretion of insulin.
TLDR
An important role for vitamin D in the endocrine functioning of the pancreas is indicated by the previously demonstrated presence of a vitamin D-dependent calcium-binding protein and cytosol receptor for the hormonal form of vitamin D, 1,25-dihydroxyvitamin D3. Expand
Regulation of pancreatic insulin and glucagon secretion.
TLDR
This review attempts, when possible, to discuss regulation of insulin and glucagon secretion as related events asrelated events in vivo and in vitro. Expand
Are Oxidative StressActivated Signaling Pathways Mediators of Insulin Resistance and -Cell
TLDR
It is proposed here that the hyperglycemia- induced, and possibly FFA-induced, activation of stress pathways plays a key role in the development of not only the late complications in type 1 and type 1 diabetes, but also the insulin resistance and impaired insulin secretion seen in type 2 diabetes. Expand
Iontophoresis of monomeric insulin analogues in vitro: effects of insulin charge and skin pretreatment.
TLDR
Monomeric insulin analogues with at least two extra negative charges can be iontophoretically delivered across hairless mouse skin, whereas insignificant flux is observed with human, hexameric insulin. Expand
Comparison of models of insulin release.
A model for insulin secretion with a storage and a labile compartment, as well as a provisionary factor, is combined with a signal model in which the signal can be the difference between anExpand
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