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UBE3A wt Allele

Known as: FLJ26981, ANCR, EPVE6AP 
Human UBE3A wild-type allele is located within 15q11-q13 and is approximately 102 kb in length. This allele, which encodes ubiquitin-protein ligase… 
National Institutes of Health

Related topics

Related topics

10 relations
15q11-q13Angelman SyndromeProtein Degradation, MetabolicUBE2C protein, human

Broader (1)

UBE3A gene

Papers overview

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Review
2015
Review
2015
Breast cancer cells: Modulation by melatonin and the ubiquitin-proteasome system – A review
2013
2013
E3 Ubiquitin Ligase E6AP Negatively Regulates Adipogenesis by Downregulating Proadipogenic Factor C/EBPalpha
CCAAT/Enhancer Binding Protein Alpha (C/EBPα) is a key transcription factor involved in the adipocyte differentiation. Here for… 
2013
2013
c-Abl phosphorylates E6AP and regulates its E3 ubiquitin ligase activity.
In human papillomavirus (HPV)-infected cells, the p53 tumor suppressor is tightly regulated by the HPV-E6-E6AP complex, which… 
2012
2012
Overexpression of ligase defective E6-associated protein, E6-AP, results in mammary tumorigenesis
E6-associated protein (E6-AP) is a dual function protein. It acts as an E3 ubiquitin-protein ligase enzyme and coactivator of… 
2010
2010
Differential functional genomic effects of anti-inflammatory phytocompounds on immune signaling
BackgroundFunctional comparative genomic analysis of the cellular immunological effects of different anti-inflammatory… 
2006
2006
Surface plasmon resonance imaging protein arrays for analysis of triple protein interactions of HPV, E6, E6AP, and p53
We have developed a surface plasmon resonance (SPR)‐based protein microarray to study protein–protein interactions in a high… 
2000
2000
The dual function steroid receptor coactivator/ubiquitin protein-ligase integrator E6-AP is overexpressed in mouse mammary tumorigenesis
Steroid receptor coactivator and corepressor proteins are important mediators of steroid receptor function. Changes in the… 
2000
2000
Development of screening systems for drugs against human papillomavirus-associated cervical cancer: based on E6-E6AP binding.
Highly Cited
1998
Highly Cited
1998
Human ubiquitin‐protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin‐conjugating enzymes
Nedd4 is a ubiquitin‐protein ligase containing a calcium/lipid‐binding domain, multiple WW domains and a C‐terminal Hect domain… 
1998
1998
UBE3A“mutations” in two unrelated and phenotypically different Angelman syndrome patients
Abstract Angelman syndrome (AS) is a rare neurodevelopmental disorder. Recently, several mutations have been found in the E6-AP… 
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