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Mdm2 promotes the rapid degradation of p53
The p53 tumour-suppressor protein exerts antiproliferative effects, including growth arrest and apoptosis, in response to various types of stress1. The activity of p53 is abrogated by mutations that… Expand
Apoptosis - the p53 network
Exposure to cellular stress can trigger the p53 tumor suppressor, a sequence-specific transcription factor, to induce cell growth arrest or apoptosis. The choice between these cellular responses is… Expand
Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
In response to environmental stress, the p53 phosphoprotein is stabilized and activated to inhibit cell growth. p53 stability and activity are negatively regulated by the murine double minute (Mdm2)… Expand
Novel zinc finger gene implicated as myc collaborator by retrovirally accelerated lymphomagenesis in Eμ-myc transgenic mice
To search for genes that can collaborate with myc in lymphomagenesis, we exploited retroviral insertional mutagenesis in E mu-myc transgenic mice. Moloney murine leukemia virus accelerated… Expand
Induction of apoptosis in HeLa cells by trans-activation-deficient p53.
- Y. Haupt, S. Rowan, E. Shaulian, K. Vousden, M. Oren
- Biology, Medicine
- Genes & development
- 1 September 1995
The p53 tumor suppressor protein is a transcriptional activator, which can mediate apoptotic cell death in a variety of cell types. To determine whether sequence-specific trans-activation is a… Expand
A functional p53-responsive intronic promoter is contained within the human mdm2 gene.
- A. Zauberman, D. Flusberg, Y. Haupt, Y. Barak, M. Oren
- Biology, Medicine
- Nucleic acids research
- 25 July 1995
The mdm2 gene is a target for transcriptional activation by the p53 tumor suppressor gene product. Previous work has revealed that the mouse mdm2 gene contains two promoters: one is located upstream… Expand
Specific loss of apoptotic but not cell‐cycle arrest function in a human tumor derived p53 mutant.
The p53 tumor‐suppressor gene product is frequently inactivated in malignancies by point mutation. Although most tumor‐derived p53 mutants show loss of sequence specific transcriptional activation,… Expand
Tyrosine phosphorylation of Mdm2 by c‐Abl: implications for p53 regulation
The p53 tumor suppressor is inhibited and destabilized by Mdm2. However, under stress conditions, this downregulation is relieved, allowing the accumulation of biologically active p53. Recently we… Expand
The cellular response to p53: the decision between life and death
The p53 tumor suppressor protein plays a crucial role in regulating cell growth following exposure to various stress stimuli. p53 induces either growth arrest, which prevents the replication of… Expand
c-Jun and p53 Activity Is Modulated by SUMO-1 Modification*
- Stefan Müller, M. Berger, F. Lehembre, Jacob-S. Seeler, Y. Haupt, A. Dejean
- Medicine, Biology
- The Journal of Biological Chemistry
- 5 May 2000
The ubiquitin-related SUMO-1 molecule has been shown recently to modify covalently a number of cellular proteins including IκBα. SUMO-1 modification was found to antagonize IκBα ubiquitination and… Expand