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Down modulation of IL‐18 expression by human papillomavirus type 16 E6 oncogene via binding to IL‐18
To understand modulation of a novel immune‐related cytokine, interleukin‐18, by human papillomavirus type (HPV) 16 oncogenes, HaCaT, normal keratinocyte cell line, and C‐33A, HPV‐negative cervicalExpand
Improvement of receptor‐mediated gene delivery to HepG2 cells using an amphiphilic gelling agent
The current findings open the possibility that a receptor‐mediated gene‐delivery system for hepatic gene therapy using ASOR–PL conjugate in combination with poloxamer 407 may be developed in the future. Expand
Gene delivery using a derivative of the protein transduction domain peptide, K-Antp.
The proposed K-Antp-mediated plasmid DNA transfection not only exhibited temperature sensitivity, reflecting the involvement of an endocytosis-mediated gene transfer mechanism similar to other known PTDs, but also temperature insensitivity, suggesting the role of an energy-independent mechanism. Expand
A composite gene delivery system consisting of polyethylenimine and an amphipathic peptide KALA
Animal viruses such as enveloped virus carry multi‐functional proteins in the virion that can mediate more than two distinct steps of a gene delivery process during the transfer of viral genome intoExpand
HPV E6 antisense induces apoptosis in CaSki cells via suppression of E6 splicing
  • C. Cho, H. Poo, +10 authors D. Yoon
  • Biology, Medicine
  • Experimental & Molecular Medicine
  • 31 May 2002
Results indicate that HPV 16 E6(AS) induces apoptosis in CaSki cells via upregulation of p53 and release of cytochrome c into cytoplasm, consequently activating procaspase-9 and procaspases-3. Expand
Improvement of gene transfer to cervical cancer cell lines using non-viral agents.
The result support the notion that VLP-PL conjugate may be a promising vector to transfer genetic materials into cancer cells and poloxamer 407 can be used for enhancing the transfection efficiency of V LP-PL Conjugate. Expand
Development of screening systems for drugs against human papillomavirus-associated cervical cancer: based on E6-E6AP binding.
E6AP immobilized on the resin produced specifically complexes with bacterially expressed E6 in a dose-dependent manner, as determined by immunoblot analysis, which was collinear with that shown in ELISA, which is a useful system for mass-screening potential drugs with rapidity and cheapness. Expand
Development of a screening system for drugs against human papillomavirus-associated cervical cancer: based on E7-Rb binding
This screening system (based on the interaction between E7 and Rb) can be a promising system in the development of drugs against cervical cancers caused by human papillomavirus infection. Expand