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Tumor Necrosis Factor Receptor

Known as: Tumor Necrosis Factor Receptors, Receptors, TNF, receptors tnf 
Members of the tumor necrosis factor receptor (TNFR) family play a key role in regulating the immune response to infection. They are cell-surface… 
National Institutes of Health

Related topics

Related topics

30 relations
Apoptosis Regulatory ProteinsCytokine Receptor GeneCytokine Signaling ProcessIn Blood

Narrower (9)

BLyS receptorCrmE protein, Vaccinia virusRELTReceptors, Tumor Necrosis Factor, Type II

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
IL-17 Signaling for mRNA Stabilization Does Not Require TNF Receptor-Associated Factor 61
IL-17 alone is a relatively weak inducer of gene expression, but cooperates with other cytokines, including TNF-α, to generate a… 
Highly Cited
2006
Highly Cited
2006
The TNF alpha converting enzyme (TACE/ADAM17) is expressed in the atherosclerotic lesions of apolipoprotein E-deficient mice: possible contribution to elevated plasma levels of soluble TNF alpha…
Highly Cited
2002
Highly Cited
2002
Association between tumor necrosis factor receptor II and familial, but not sporadic, rheumatoid arthritis: evidence for genetic heterogeneity.
OBJECTIVE Tumor necrosis factor alpha (TNFalpha) binds the receptors TNFRI and TNFRII. Results of genome scans have suggested… 
Highly Cited
2001
Highly Cited
2001
Combination immunotherapy with soluble tumor necrosis factor receptors plus interleukin 1 receptor antagonist decreases sepsis mortality
ObjectiveInhibition of tumor necrosis factor (TNF) or interleukin 1 (IL-1) alone has not improved sepsis survival in human… 
Highly Cited
1998
Highly Cited
1998
Nuclear Factor kB-independent Cytoprotective Pathways Originating at Tumor Necrosis Factor Receptor-associated Factor 2*
Most normal and neoplastic cell types are resistant to tumor necrosis factor (TNF) cytotoxicity unless cotreated with protein or… 
Review
1996
Review
1996
Molecular, structural, and biological characteristics of the tumor necrosis factor ligand superfamily
  • H. Gruss
  • International journal of clinical & laboratory…
  • 1996
  • Corpus ID: 24424910
The tumor necrosis factor receptor superfamily at present consists of ten different transmembrane (type I) glycoproteins with… 
Review
1995
Review
1995
How do tumor necrosis factor receptors work?
Quite suddenly, a new level of understanding has been attached to the TNF ligand and receptor families. Many of the proximal… 
Highly Cited
1993
Highly Cited
1993
Circulating soluble tumor necrosis factor receptors, interleukin-2 receptors, tumor necrosis factor alpha, and interleukin-6 levels in rheumatoid arthritis. Longitudinal evaluation during…
OBJECTIVE To assess whether circulating concentrations of soluble tumor necrosis factor receptors (sTNFR; p55 and p75), soluble… 
Highly Cited
1992
Highly Cited
1992
Antiviral activity of tumor necrosis factor is signaled through the 55-kDa type I TNF receptor [corrected].
Agonist antibodies (Ab) to the two TNF receptors, TNF-R1 (55 kDa) and TNF-R2 (75 kDa), have been shown to signal many of the… 
Highly Cited
1990
Highly Cited
1990
Molecular cloning and expression of human and rat tumor necrosis factor receptor chain (p60) and its soluble derivative, tumor necrosis factor-binding protein.
Tumor necrosis factor-alpha (TNF-alpha), a protein released by activated macrophages, is involved in a wide variety of human… 
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