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Tumor Necrosis Factor Receptor

Known as: Tumor Necrosis Factor Receptors, Receptors, TNF, receptors tnf 
Members of the tumor necrosis factor receptor (TNFR) family play a key role in regulating the immune response to infection. They are cell-surface… 
National Institutes of Health

Related topics

Related topics

30 relations
Apoptosis Regulatory ProteinsCytokine Receptor GeneCytokine Signaling ProcessIn Blood
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Narrower (9)

BLyS receptorCrmE protein, Vaccinia virusRELTReceptors, Tumor Necrosis Factor, Type II
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2001
Review
2001
Toll-like receptors: critical proteins linking innate and acquired immunity
Recognition of pathogens is mediated by a set of germline-encoded receptors that are referred to as pattern-recognition receptors… 
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Review
1999
Review
1999
Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families.
Osteoblasts/stromal cells are essentially involved in osteoclast differentiation and function through cell-to-cell contact (Fig… 
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Highly Cited
1999
Highly Cited
1999
Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand.
  • H. Hsu, D. Lacey, +18 authors W. Boyle
  • Proceedings of the National Academy of Sciences…
  • 1999
  • Corpus ID: 2824245
A receptor that mediates osteoprotegerin ligand (OPGL)-induced osteoclast differentiation and activation has been identified via… 
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Highly Cited
1999
Highly Cited
1999
A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate.
BACKGROUND Patients treated with methotrexate for rheumatoid arthritis often improve but continue to have active disease. This… 
Highly Cited
1997
Highly Cited
1997
Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein.
BACKGROUND Tumor necrosis factor (TNF) is a proinflammatory cytokine involved in the pathogenesis of rheumatoid arthritis, and… 
Highly Cited
1996
Highly Cited
1996
Tumor Necrosis Factor-α and Tumor Necrosis Factor Receptors in the Failing Human Heart
Background Tumor necrosis factor-α (TNF-α) is a proinflammatory cytokine that produces negative inotropic effects in the heart… 
Highly Cited
1995
Highly Cited
1995
The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor
The 60 kDa tumor necrosis factor receptor (TNFR60) is regarded as the major signal transducer of TNF-induced cellular responses… 
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Highly Cited
1995
Highly Cited
1995
The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family
The cytoplasmic C-terminus of Epstein-Barr virus (EBV) latent infection membrane protein 1 (LMP1) is essential for B lymphocyte… 
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Highly Cited
1994
Highly Cited
1994
A novel family of putative signal transducers associated with the cytoplasmic domain of the 75 kDa tumor necrosis factor receptor
Mutational analysis identified a C-terminal region of 78 amino acids within the cytoplasmic domain of the human 75 kDa tumor… 
Highly Cited
1993
Highly Cited
1993
Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection
The multiple biological activities of tumor necrosis factor (TNF) are mediated by two distinct cell surface receptors of 55 kd… 
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