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- Publications
- Influence
Signalling pathways of the TNF superfamily: a double-edged sword
- B. Aggarwal
- Medicine, Biology
- Nature Reviews Immunology
- 1 September 2003
Two different tumour-necrosis factors (TNFs), first isolated in 1984, were found to be cytotoxic to tumour cells and to induce tumour regression in mice. Research during the past two decades has… Expand
Oxidative stress, inflammation, and cancer: how are they linked?
- S. Reuter, S. Gupta, M. Chaturvedi, B. Aggarwal
- Biology, Medicine
- Free radical biology & medicine
- 1 December 2010
Extensive research during the past 2 decades has revealed the mechanism by which continued oxidative stress can lead to chronic inflammation, which in turn could mediate most chronic diseases… Expand
Bioavailability of curcumin: problems and promises.
- P. Anand, A. B. Kunnumakkara, R. Newman, B. Aggarwal
- Chemistry, Medicine
- Molecular pharmaceutics
- 14 November 2007
Curcumin, a polyphenolic compound derived from dietary spice turmeric, possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic… Expand
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.
- K. Natarajan, S. Singh, T. Burke, D. Grunberger, B. Aggarwal
- Chemistry, Medicine
- Proceedings of the National Academy of Sciences…
- 20 August 1996
Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, is known to have antimitogenic, anticarcinogenic, antiinflammatory, and immunomodulatory properties. The… Expand
Molecular targets of dietary agents for prevention and therapy of cancer.
- B. Aggarwal, S. Shishodia
- Biology, Medicine
- Biochemical pharmacology
- 14 May 2006
While fruits and vegetables are recommended for prevention of cancer and other diseases, their active ingredients (at the molecular level) and their mechanisms of action less well understood.… Expand
Cancer is a Preventable Disease that Requires Major Lifestyle Changes
- P. Anand, A. B. Kunnumakkara, +5 authors B. Aggarwal
- Medicine
- Pharmaceutical Research
- 15 July 2008
This year, more than 1 million Americans and more than 10 million people worldwide are expected to be diagnosed with cancer, a disease commonly believed to be preventable. Only 5–10% of all cancer… Expand
Anticancer potential of curcumin: preclinical and clinical studies.
- B. Aggarwal, A. Kumar, A. Bharti
- Medicine
- Anticancer research
- 2003
Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both prevent… Expand
Curcumin as "Curecumin": from kitchen to clinic.
- A. Goel, A. B. Kunnumakkara, B. Aggarwal
- Medicine
- Biochemical pharmacology
- 15 February 2008
Although turmeric (Curcuma longa; an Indian spice) has been described in Ayurveda, as a treatment for inflammatory diseases and is referred by different names in different cultures, the active… Expand
Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.
- B. Aggarwal, A. Bhardwaj, R. Aggarwal, N. Seeram, S. Shishodia, Y. Takada
- Medicine
- Anticancer research
- 1 September 2004
Resveratrol, trans-3,5,4'-trihydroxystilbene, was first isolated in 1940 as a constituent of the roots of white hellebore (Veratrum grandiflorum O. Loes), but has since been found in various plants,… Expand
Nuclear factor-kappaB: the enemy within.
- B. Aggarwal
- Biology, Medicine
- Cancer cell
- 1 September 2004
Numerous lines of investigation suggest that nuclear factor NF-kappaB, a proinflammatory transcription factor, could promote tumorigenesis. Various inflammatory agents, carcinogens, tumor promoters,… Expand