Signalling pathways of the TNF superfamily: a double-edged sword
- B. Aggarwal
- Biology, MedicineNature reviews. Immunology
- 1 September 2003
Two different tumour-necrosis factors, first isolated in 1984, were found to be cytotoxic to tumour cells and to induce tumour regression in mice, and blockers of TNF have been approved for human use in treating TNF-linked autoimmune diseases.
Oxidative stress, inflammation, and cancer: how are they linked?
Bioavailability of curcumin: problems and promises.
Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease.
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.
- K. Natarajan, S. Singh, T. Burke, D. Grunberger, B. Aggarwal
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 20 August 1996
The results demonstrate that CAPE is a potent and a specific inhibitor of NF-kappa B activation and this may provide the molecular basis for its multiple immunomodulatory and antiinflammatory activities.
Molecular targets of dietary agents for prevention and therapy of cancer.
Cancer is a Preventable Disease that Requires Major Lifestyle Changes
Evidence that inflammation is the link between the agents/factors that cause cancer and the agents that prevent it is presented and evidence that cancer is a preventable disease that requires major lifestyle changes is provided.
Anticancer potential of curcumin: preclinical and clinical studies.
Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.
Curcumin as "Curecumin": from kitchen to clinic.
Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.
- B. Aggarwal, A. Bhardwaj, Rishi S Aggarwal, N. Seeram, S. Shishodia, Y. Takada
- BiologyAnticancer Research
- 1 September 2004
In vivo, resveratrol blocks the multistep process of carcinogenesis at various stages: it blocks carcinogen activation by inhibiting aryl hydrocarbon-induced CYP1A1 expression and activity, and suppresses tumor initiation, promotion and progression.
Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.