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Signalling pathways of the TNF superfamily: a double-edged sword
- B. Aggarwal
- Medicine, BiologyNature Reviews Immunology
- 1 September 2003
Two different tumour-necrosis factors, first isolated in 1984, were found to be cytotoxic to tumour cells and to induce tumour regression in mice, and blockers of TNF have been approved for human use in treating TNF-linked autoimmune diseases.
Oxidative stress, inflammation, and cancer: how are they linked?
- Simone Reuter, Subash C. Gupta, M. Chaturvedi, B. Aggarwal
- Biology, MedicineFree radical biology & medicine
- 1 December 2010
Observations to date suggest that oxidative stress, chronic inflammation, and cancer are closely linked.
Bioavailability of curcumin: problems and promises.
- P. Anand, A. B. Kunnumakkara, R. Newman, B. Aggarwal
- Chemistry, MedicineMolecular pharmaceutics
- 14 November 2007
Enhanced bioavailability of curcumin in the near future is likely to bring this promising natural product to the forefront of therapeutic agents for treatment of human disease.
Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.
- K. Natarajan, S. Singh, T. Burke, D. Grunberger, B. Aggarwal
- Chemistry, MedicineProceedings of the National Academy of Sciences…
- 20 August 1996
The results demonstrate that CAPE is a potent and a specific inhibitor of NF-kappa B activation and this may provide the molecular basis for its multiple immunomodulatory and antiinflammatory activities.
Anticancer potential of curcumin: preclinical and clinical studies.
Evidence has also been presented to suggest that curcumin can suppress tumor initiation, promotion and metastasis, and Pharmacologically,Curcumin has been found to be safe.
Molecular targets of dietary agents for prevention and therapy of cancer.
Evidence is presented that numerous agents identified from fruits and vegetables can interfere with several cell-signaling pathways and the active principle identified in fruit and vegetables and the molecular targets modulated may be the basis for how these dietary agents not only prevent but also treat cancer and other diseases.
Cancer is a Preventable Disease that Requires Major Lifestyle Changes
Evidence that inflammation is the link between the agents/factors that cause cancer and the agents that prevent it is presented and evidence that cancer is a preventable disease that requires major lifestyle changes is provided.
Curcumin as "Curecumin": from kitchen to clinic.
Curcumin, a spice once relegated to the kitchen shelf, has moved into the clinic and may prove to be "Curecumin", a therapeutic agent in wound healing, diabetes, Alzheimer disease, Parkinson disease, cardiovascular disease, pulmonary disease, and arthritis.
Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.
- B. Aggarwal, A. Bhardwaj, Rishi S Aggarwal, N. Seeram, S. Shishodia, Y. Takada
- MedicineAnticancer research
- 1 September 2004
In vivo, resveratrol blocks the multistep process of carcinogenesis at various stages: it blocks carcinogen activation by inhibiting aryl hydrocarbon-induced CYP1A1 expression and activity, and suppresses tumor initiation, promotion and progression.
Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases.
Evidence for the potential role of curcumin in the prevention and treatment of various proinflammatory chronic diseases is provided and its features, combined with the pharmacological safety and negligible cost, renderCurcumin an attractive agent to explore further.