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Signalling pathways of the TNF superfamily: a double-edged sword
  • B. Aggarwal
  • Medicine, Biology
  • Nature Reviews Immunology
  • 1 September 2003
Two different tumour-necrosis factors (TNFs), first isolated in 1984, were found to be cytotoxic to tumour cells and to induce tumour regression in mice. Research during the past two decades hasExpand
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Oxidative stress, inflammation, and cancer: how are they linked?
Extensive research during the past 2 decades has revealed the mechanism by which continued oxidative stress can lead to chronic inflammation, which in turn could mediate most chronic diseasesExpand
  • 2,886
  • 107
Bioavailability of curcumin: problems and promises.
Curcumin, a polyphenolic compound derived from dietary spice turmeric, possesses diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenicExpand
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Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.
Caffeic acid phenethyl ester (CAPE), an active component of propolis from honeybee hives, is known to have antimitogenic, anticarcinogenic, antiinflammatory, and immunomodulatory properties. TheExpand
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Molecular targets of dietary agents for prevention and therapy of cancer.
While fruits and vegetables are recommended for prevention of cancer and other diseases, their active ingredients (at the molecular level) and their mechanisms of action less well understood.Expand
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Cancer is a Preventable Disease that Requires Major Lifestyle Changes
This year, more than 1 million Americans and more than 10 million people worldwide are expected to be diagnosed with cancer, a disease commonly believed to be preventable. Only 5–10% of all cancerExpand
  • 1,533
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Anticancer potential of curcumin: preclinical and clinical studies.
Curcumin (diferuloylmethane) is a polyphenol derived from the plant Curcuma longa, commonly called turmeric. Extensive research over the last 50 years has indicated this polyphenol can both preventExpand
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Curcumin as "Curecumin": from kitchen to clinic.
Although turmeric (Curcuma longa; an Indian spice) has been described in Ayurveda, as a treatment for inflammatory diseases and is referred by different names in different cultures, the activeExpand
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Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.
Resveratrol, trans-3,5,4'-trihydroxystilbene, was first isolated in 1940 as a constituent of the roots of white hellebore (Veratrum grandiflorum O. Loes), but has since been found in various plants,Expand
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Nuclear factor-kappaB: the enemy within.
  • B. Aggarwal
  • Biology, Medicine
  • Cancer cell
  • 1 September 2004
Numerous lines of investigation suggest that nuclear factor NF-kappaB, a proinflammatory transcription factor, could promote tumorigenesis. Various inflammatory agents, carcinogens, tumor promoters,Expand
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