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Tumor necrosis factor signaling
TLDR
Some general aspects of this fascinating molecule are covered and then the molecular mechanisms of TNF signal transduction will be addressed, including the multiple facets of crosstalk between the various signalling pathways engaged by TNF. Expand
The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor
TLDR
It is shown here that the transmembrane form of TNF is superior to soluble TNF in activating TNFR80 in activating TNF-induced cellular responses in various systems such as T cell activation, thymocyte proliferation, and granulocyte/macrophage colony-stimulating factor production. Expand
The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor.
TLDR
The stability of the TNF-TNF receptor complexes as a rationale for their differential signaling capability is suggested and the lower signaling capability of homotrimeric lymphotoxin, compared with TNF, correlates with a lower Stability of the lymphot toxin-T NF-R1 complex at 37 degrees C. Expand
NF-κB Inducers Upregulate cFLIP, a Cycloheximide-Sensitive Inhibitor of Death Receptor Signaling
TLDR
CFLIP expression was able to reverse the proapoptotic effect of NF-κB inhibition, and Western blot analysis revealed that cFLIP, but not TRAF1, A20, and cIAP2, expression levels rapidly decrease upon CHX treatment. Expand
Bistability Analyses of a Caspase Activation Model for Receptor-induced Apoptosis*
TLDR
The current knowledge of the molecular mechanisms of the death-receptor-activated caspase cascade is translated into a mathematical model and a reduction down to the apoptotic core machinery enables the application of analytical mathematical methods to evaluate the system behavior within a wide range of parameters. Expand
The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators.
TLDR
This review addresses the structural and molecular basis of TRAF protein functions and highlights their role in cytokine signalling. Expand
Induction of cell death by tumour necrosis factor (TNF) receptor 2, CD40 and CD30: a role for TNF‐R1 activation by endogenous membrane‐anchored TNF
TLDR
It is demonstrated in different cellular systems that cytotoxic effects induced by TNF‐R2, CD40 and CD30 are mediated by endogenous production of TNF and autotropic or paratropic activation of T NF‐R1. Expand
NFκB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP
TLDR
Protection against Fas-induced apoptosis in a FLIP-independent manner converted a proapoptotic Fas signal into an inflammatory NFκB-related response. Expand
Reverse Signaling Through Transmembrane TNF Confers Resistance to Lipopolysaccharide in Human Monocytes and Macrophages1
TLDR
The results support the idea of a bidirectional cross-talk between MO and EC and show that reverse signaling through mTNF mediated LPS resistance in MO/MΦ as indicated by the down-regulation of LPS-induced soluble TNF and IL-6 as well as IL-1 andIL-10. Expand
Tumor necrosis factor receptor-associated factor (TRAF) 2 and its role in TNF signaling.
TLDR
This review focuses on the molecular mechanisms that underlay signal initiation by TNF-R2, with particular consideration of the role of TRAF 2, and highlights the importance of this molecule for the integration of such antagonizing pathways as death induction and NF-kappaB-mediated surviving signals. Expand
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