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Tryptophan 5-monooxygenase

Known as: Tryptophan Monooxygenase, Monooxygenase, Tryptophan, Hydroxylase, Tryptophan 
An enzyme that catalyzes the hydroxylation of TRYPTOPHAN to 5-HYDROXYTRYPTOPHAN in the presence of NADPH and molecular oxygen. It is important in the… 
National Institutes of Health

Related topics

Related topics

15 relations
In BloodProcess of secretionTPH1 geneTPH2 gene

Broader (2)

Mixed Function OxygenasesOxygenases

Narrower (2)

TPH1 protein, humanTph1 protein, mouse

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
0021-972X/05/$15.00/0 The Journal of Clinical Endocrinology & Metabolism 90(2):992–1000 Printed in U.S.A. Copyright © 2005 by The Endocrine Society doi: 10.1210/jc.2004-1429 Human Lymphocyte…
  • 2004
  • Corpus ID: 17820410
Highly Cited
1998
Highly Cited
1998
No association of the tryptophan hydroxylase gene with bipolar affective disorder, unipolar affective disorder, or suicidal behaviour in major affective disorder.
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of 5-hydroxytryptamine (5-HT). An association study in… 
Highly Cited
1997
Highly Cited
1997
Gastroprotective activity of melatonin and its precursor, L-tryptophan, against stress-induced and ischaemia-induced lesions is mediated by scavenge of oxygen radicals.
BACKGROUND Melatonin, a pineal hormone that is biosynthesized from L-tryptophan, is known to scavenge oxygen free radicals and to… 
Highly Cited
1991
Highly Cited
1991
Distribution of GAP-43 mRNA in the brain stem of adult rats as evidenced by in situ hybridization: localization within monoaminergic neurons
Using in situ hybridization, we examined the distribution of the mRNA encoding for the growth-associated protein GAP-43 in the… 
Highly Cited
1975
Highly Cited
1975
Tryptophan hydroxylase. Purification and some properties of the enzyme from rabbit hindbrain.
Highly Cited
1973
Highly Cited
1973
Stimulation of human prolactin secretion by intravenous infusion of L-tryptophan.
Previous studies have demonstrated that the secretion of human prolactin is regulated primarily by factors that influence… 
Highly Cited
1973
Highly Cited
1973
Temporal changes in amine synthesizing enzymes of rat extrapyramidal structures after hemitransections or 6-hydroxydopamine administration.
Highly Cited
1972
Highly Cited
1972
Narcotic Drugs: Effects on the Serotonin Biosynthetic Systems of the Brain
The effects of short- and long-term administration of morphine on the activity of two measurable forms of rat brain tryptophan… 
Highly Cited
1968
Highly Cited
1968
Alcohol Preference in the Rat: Reduction Following Depletion of Brain Serotonin
Preference for ethyl alcohol was significantly reduced or totally abolished in rats given orally p-chlorophenylalanine, a… 
Highly Cited
1968
Highly Cited
1968
THE DISTRIBUTION OF TRYPTOPHAN HYDROXYLASE IN CAT BRAIN
Abstract— The distribution of tryptophan hydroxylase in the cat brain was investigated and found to parallel roughly the… 
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