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TPH1 gene

Known as: TPH1, tryptophan 5-monooxygenase, TPH 
This gene plays a role in amino acid metabolism.
National Institutes of Health

Related topics

Related topics

5 relations
Oxidation-ReductionSerotonin ProductionTPH1 protein, humanTPH2 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2013
Highly Cited
2013
Effectiveness and potential ecological effects of offshore surface dispersant use during the Deepwater Horizon oil spill: a retrospective analysis of monitoring data
The Special Monitoring of Applied Response Technologies (SMART) program was used during the Deepwater Horizon oil spill as a… 
Highly Cited
2008
Highly Cited
2008
Tryptophan hydroxylase and catechol-O-methyltransferase gene polymorphisms: relationships to monoamine metabolite concentrations in CSF of healthy volunteers
Concentrations of monoamine metabolites (MM) in lumbar cerebrospinal fluid (CSF) have been used extensively as indirect estimates… 
Highly Cited
2007
Highly Cited
2007
Candidate Gene Polymorphisms in the Serotonergic Pathway: Influence on Depression Symptomatology in an Elderly Population
Highly Cited
2006
Highly Cited
2006
Haplotype Analysis Reveals Tryptophan Hydroxylase (TPH) 1 Gene Variants Associated with Major Depression
Review
2006
Review
2006
Further clarification of the contribution of the tryptophan hydroxylase (TPH) gene to suicidal behavior using systematic allelic and genotypic meta-analyses
Suicide is a major public health issue, especially in western countries, accounting for approximately 1 million deaths every year… 
Highly Cited
2002
Highly Cited
2002
Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders.
Variants of the functional polymorphism in the serotonin transporter (upstream regulatory region: 5-HTTLPR), the tryptophan… 
Highly Cited
2001
Highly Cited
2001
Tryptophan hydroxylase gene variant and smoking behavior.
Approximately 50% of the variance in smoking behavior is attributable to genetic factors. Genes in the serotonin system are… 
Highly Cited
1999
Highly Cited
1999
Tryptophan hydroxylase gene and response to lithium prophylaxis in mood disorders.
Highly Cited
1998
Highly Cited
1998
No association of the tryptophan hydroxylase gene with bipolar affective disorder, unipolar affective disorder, or suicidal behaviour in major affective disorder.
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of 5-hydroxytryptamine (5-HT). An association study in… 
Highly Cited
1992
Highly Cited
1992
Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism.
The identification of polymorphic alleles at loci coding for functional genes is crucial for genetic association and linkage… 
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