TPH1 protein, human

Known as: TPH1, Tryptophan 5-Monooxygenase 1, EC 1.14.16.4 
Tryptophan 5-hydroxylase 1 (444 aa, ~51 kDa) is encoded by the human TPH1 gene. This protein plays a role in the metabolism of tryptophan.
National Institutes of Health

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2013
2013
BACKGROUND Selective serotonin reuptake inhibitors (SSRIs) are widely used antidepressants and one of the most commonly used… (More)
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2012
2012
The gut contains the bulk of the body's serotonin (5-hydroxytryptamine, 5-HT); nevertheless, the physiological role that enteric… (More)
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Highly Cited
2011
Highly Cited
2011
The gut contains a large 5-HT pool in enterochromaffin (EC) cells and a smaller 5-HT pool in the enteric nervous system (ENS… (More)
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Highly Cited
2010
Highly Cited
2010
Upregulation of the functional beta cell mass is required to match the physiological demands of mother and fetus during pregnancy… (More)
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2009
2009
BACKGROUND The tryptophan hydroxylase 1 (TPH1) gene is reported to be associated with suicidal behavior. This has not been… (More)
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Highly Cited
2007
Highly Cited
2007
Dysregulation of brain serotonin transmission is an important contributing factor in many psychiatric disorders. Tryptophan… (More)
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2007
2007
Tryptophan hydroxylase-1 (TPH1) is the rate-limiting enzyme in serotonin biosynthesis, and selective serotonin reuptake… (More)
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Highly Cited
2004
Highly Cited
2004
Dysregulation of brain serotonin contributes to many psychiatric disorders. Tryptophan hydroxylase-2 (Tph2), rather than Tph1, is… (More)
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Highly Cited
1987
Highly Cited
1987
We have found that the 14-3-3 protein, an acidic neuronal protein, is substantially identical to the 'activator' protein [(1981… (More)
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1981
1981
Rat brain tryptophan 5-monooxygenase was activated by incubation with ATP, Mg2+, calmodulin, and micromolar concentrations of Ca2… (More)
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