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Tiagabine hydrochloride

Known as: (-)-(R)-1-(4,4-Bis(3-methyl-2-thienyl)-3-butenyl)nipecotic Acid, Hydrochloride, 3-Piperidinecarboxylic Acid, 1-(4,4-bis(3-methyl-2-thienyl)-3-buten-yl)-, Hydrochloride,(R)-, tiagabine hcl 
The hydrochloride salt form of tiagabine, a nipecotic acid derivative with anticonvulsant property. Tiagabine hydrochloride inhibits the gamma… 
National Institutes of Health

Related topics

Related topics

9 relations
Antiepileptic AgentsBipolar DisorderDrug AllergyEpilepsies, Partial

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Isobolographic Analysis of Antiseizure Activity of the GABA Type A Receptor-Modulating Synthetic Neurosteroids Brexanolone and Ganaxolone with Tiagabine and Midazolam
Epilepsy is often treated with a combination of antiepileptic drugs. Although neurosteroids are potent anticonvulsants, little is… 
2016
2016
Acute cognitive impact of antiseizure drugs in naive rodents and corneal‐kindled mice
Some antiseizure drugs (ASDs) are associated with cognitive liability in patients with epilepsy, thus ASDs without this risk… 
Review
2005
Review
2005
New targets for neuropathic pain therapeutics
Neuropathic pain (NeP) is initiated by a lesion or dysfunction in the nervous system. Unlike physiological pain it serves no… 
2004
2004
Low-dose tiagabine effectiveness in anxiety disorders.
BACKGROUND Gamma-aminobutyric acid (GABA), the predominant inhibitory neurotransmitter of the central nervous system, is involved… 
2001
2001
Treatment of painful sensory neuropathy with tiagabine: A pilot study
To evaluate the effect of tiagabine hydrochloride in painful neuropathy in a pilot, open-label study. Painful neuropathy is… 
Highly Cited
1999
Highly Cited
1999
Tiagabine antinociception in rodents depends on GABA(B) receptor activation: parallel antinociception testing and medial thalamus GABA microdialysis.
Review
1997
Review
1997
Clinical Significance of Animal Seizure Models and Mechanism of Action Studies of Potential Antiepileptic Drugs
Summary: More than 50 million persons worldwide suffer from epilepsy, many of whom are refractory to treatment with standard… 
1997
1997
The Pharmacokinetics of Tiagabine in Healthy Elderly Volunteers and Elderly Patients with Epilepsy
The pharmacokinetics of tiagabine after single‐dose (8 mg) and multiple‐dose (3 mg, three‐times daily for four days… 
Highly Cited
1995
Highly Cited
1995
Postischemic inhibition of GABA reuptake by tiagabine slows neuronal death in the gerbil hippocampus
The neuroprotective effects of enhancing neuronal inhibition with a γ‐aminobutyric acid (GABA) uptake inhibitor were studied in… 
1991
1991
Reductive alkylation of DNA by mitomycin A, a mitomycin with high redox potential.
The mitomycins are a group of antitumor antibiotics that covalently bind to DNA upon reductive activation. Mitomycin A (1b; MA… 
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