Neurosteroids: endogenous role in the human brain and therapeutic potentials.
- D. Reddy
- Biology, MedicineProgress in Brain Research
- 2010
Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABAA Receptor Function and Seizure Susceptibility
- D. Reddy, M. Rogawski
- BiologyJournal of Neuroscience
- 1 May 2002
Evidence is provided that GABAA receptor-modulating neurosteroids derived from deoxycorticosterone play a role in stress-related changes in seizure control and that DOC is a mediator of the physiological effects of acute stress that could contribute to stress-inducedChanges in seizure susceptibility.
The Testosterone-Derived Neurosteroid Androstanediol Is a Positive Allosteric Modulator of GABAA Receptors
- D. Reddy, Kuihuan Jian
- Biology, MedicineJournal of Pharmacology and Experimental…
- 1 September 2010
Androstanediol could be a neurosteroid mediator of testosterone actions on neuronal excitability and seizure susceptibility via its activity as a GABAA receptor modulator and that androStanediol may play a key role in men with epilepsy, especially during the age-related decline in androgen levels.
Experimental Models of Status Epilepticus and Neuronal Injury for Evaluation of Therapeutic Interventions
- D. Reddy, Ramkumar Kuruba
- BiologyInternational Journal of Molecular Sciences
- 1 September 2013
Current experimental models of status epilepticus (SE) and neuronal injury for use in the screening of new therapeutic agents and novel mechanism-based or clinically relevant models are essential to identify new therapies for SE and neuroprotective interventions.
Role of neurosteroids in catamenial epilepsy
- D. Reddy
- Medicine, PsychologyEpilepsy Research
- 1 December 2004
Is there a physiological role for the neurosteroid THDOC in stress-sensitive conditions?
- D. Reddy
- Biology, PsychologyTIPS - Trends in Pharmacological Sciences
- 1 March 2003
Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself.
- D. Reddy, M. Rogawski
- Biology, MedicineJournal of Pharmacology and Experimental…
- 1 December 2000
It is concluded that there is no tolerance to the anticonvulsant activity of ganaxolone nor is there cross-tolerance to ganxolone when tolerance develops to diazepam, however, there is cross-Tolerance todiazepam with chronic ganAXolone treatment.
Clinical pharmacokinetic interactions between antiepileptic drugs and hormonal contraceptives
- D. Reddy
- Medicine, BiologyExpert Review of Clinical Pharmacology
- 1 March 2010
The pharmacokinetic interactions between antiepileptic drugs (AEDs) and hormonal contraceptives and the rational strategies that may overcome these risks are described.
Ganaxolone suppression of behavioral and electrographic seizures in the mouse amygdala kindling model
- D. Reddy, M. Rogawski
- Biology, PsychologyEpilepsy Research
- 1 May 2010
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