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Key factors in the discovery and development of new antiepileptic drugs
TLDR
The emerging knowledge on the pathological basis of epilepsy is reviewed and how it might best be used in the design of new therapeutics is discussed.
Characterization of the anticonvulsant properties of Ganaxolone (CCD 1042; 3α-hydroxy-3β-methyl-5α-pregnan-20-one), a selective, high-affinity, steroid modulator of the γ-aminobutyric acid(A) receptor
TLDR
Data indicate that ganaxolone is a high-affinity, stereoselective, positive allosteric modulator of the GABAA receptor complex that exhibits potent anticonvulsant activity across a range of animal procedures.
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