Clinical Significance of Animal Seizure Models and Mechanism of Action Studies of Potential Antiepileptic Drugs

@article{White1997ClinicalSO,
  title={Clinical Significance of Animal Seizure Models and Mechanism of Action Studies of Potential Antiepileptic Drugs},
  author={H. White},
  journal={Epilepsia},
  year={1997},
  volume={38}
}
Summary: More than 50 million persons worldwide suffer from epilepsy, many of whom are refractory to treatment with standard antiepileptic drugs (AEDs). Fortunately, new AEDs commercialized since 1990 are improving the clinical outlook for many patients. Our growing understanding of anticonvulsant mechanisms and the relevance of preclinical animal studies to clinical antiepileptic activity have already contributed to the design of several new AEDs and should be increasingly beneficial to… Expand
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