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Menthol: a natural analgesic compound
Menthol, after topical application, causes a feeling of coolness due to stimulation of 'cold' receptors by inhibiting Ca++ currents of neuronal membranes. Since Ca++ channel blockers are endowed withExpand
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Role of histamine in rodent antinociception
1 Effects of substances which are able to alter brain histamine levels on the nociceptive threshold were investigated in mice and rats by means of tests inducing three different kinds of noxiousExpand
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Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype
The activation of alpha2-adrenoceptors has been reported to impair memory functions in both rats and humans. The alpha2-adrenoceptor subtype responsible for this detrimental effect is still unknown.Expand
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Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes.
The administration of the ryanodine receptor (RyR) agonist 4-Cmc (0.003-9 nmol per mouse intracerebroventricularly [i.c.v.]) ameliorated memory functions, whereas the RyR antagonist ryanodineExpand
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Effect of potassium channel modulators in mouse forced swimming test
The effect of intracerebroventricular (i.c.v.) administration of different potassium channel blockers (tetraethylammonium, apamin, charybdotoxin, gliquidone), potassium channel openers (pinacidil,Expand
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Tiagabine antinociception in rodents depends on GABA(B) receptor activation: parallel antinociception testing and medial thalamus GABA microdialysis.
The effects of a new antiepileptic drug, tiagabine, (R)-N-[4,4-di-(3-methylthien-2-yl)but-3-enyl] nipecotic acid hydrochloride, were studied in mice and rats in antinociceptive tests, using threeExpand
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Mouse light/dark box test reveals anxiogenic-like effects by activation of histamine H1 receptors
Effects of substances that are able to alter the histamine level, a histamine H(1)-receptor agonist and antagonist, and a histamine H(2)-receptor agonist were investigated in an anxiety-like state inExpand
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Role of 5-HT4 receptors in the mouse passive avoidance test.
The effects of the administration of different 5-HT4 receptor antagonists (SDZ 205557, GR 125487) and 5-HT4 receptor agonists (BIMU 1, BIMU 8) on memory processes were evaluated in the mouse passiveExpand
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Analgesic and Antineuropathic Drugs Acting Through Central Cholinergic Mechanisms
The role of muscarinic and nicotinic cholinergic receptors in analgesia and neuropathic pain relief is relatively unknown. This review describes how such drugs induce analgesia or alleviateExpand
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Neuroprotective effects of acetyl‐L‐carnitine on neuropathic pain and apoptosis: A role for the nicotinic receptor
Several pathologies related to nervous tissue alterations are characterized by a chronic pain syndrome defined by persistent or paroxysmal pain independent or dependent on a stimulus.Expand
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