• Publications
  • Influence
Menthol: a natural analgesic compound
TLDR
Results indicate that (-)-menthol is endowed with analgesic properties mediated through a selective activation of kappa-opioid receptors.
Role of histamine in rodent antinociception
TLDR
Effects of substances which are able to alter brain histamine levels on the nociceptive threshold were investigated in mice and rats by means of tests inducing three different kinds of noxious stimuli: mechanical (paw pressure), chemical (abdominal constriction) and thermal (hot plate) and l‐Histidine HCl dose‐dependently induced a slowly occurring antinociception.
Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype
TLDR
Results indicate that clonidine and guanabenz impaired memory processes in a mouse passive avoidance paradigm through the selective activation of the alpha2A-adrenoceptor subtype.
Tiagabine antinociception in rodents depends on GABA(B) receptor activation: parallel antinociception testing and medial thalamus GABA microdialysis.
TLDR
It is suggested that tiagabine causes antinociception due to raised endogenous GABA levels which in turn activate GABA(B) receptors.
Mouse light/dark box test reveals anxiogenic-like effects by activation of histamine H1 receptors
TLDR
It is suggested that the histaminergic system modulates anxiety-like states via the activation of both postsynaptic receptors in a contrasting manner: activation of the H(1) receptor causes an anxiogenic-like effect, while that of theH(2) receptors reduces anxiousness.
Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes.
TLDR
The findings showed the involvement of type 2 and type 3 RyR in the modulation of memory functions identifying these cerebral RyR isoforms as critical targets underlying memory processes.
Effect of potassium channel modulators in mouse forced swimming test
TLDR
Results suggest that modulation of potassium channels plays an important role in the regulation of immobility time in the mouse forced swimming test, and that potassium channels modulators and the mKv1.c.1 aODN did not impair motor coordination, as revealed by the rota rod test.
Analgesic and Antineuropathic Drugs Acting Through Central Cholinergic Mechanisms
TLDR
It is proposed that full agonists of muscarinic or nicotinic receptors should be avoided and agents that are able to increase synthesis and release of acetylcholine from cholinergic neurons are used.
Role of 5-HT4 receptors in the mouse passive avoidance test.
TLDR
The results suggest that the modulation of 5-HT4 receptors plays an important role in the regulation of memory processes and the 5- HT4 receptor antagonists may represent pharmacological tools for investigation of new potential antiamnesic drugs.
Neuroprotective effects of acetyl‐L‐carnitine on neuropathic pain and apoptosis: A role for the nicotinic receptor
TLDR
In a model of peripheral neuropathy obtained by the loose ligation of the rat sciatic nerve, acetyl‐L‐Carnitine (ALCAR) was able to reduce hyperalgesia and apoptosis and different mechanisms for the analgesic and the antineuropathic effect of ALCAR are described.
...
1
2
3
4
5
...