Thymidine Kinase

Known as: EC 2.7.1.21, Kinase, Deoxypyrimidine, Kinase, Thymidine 
An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as… (More)
National Institutes of Health

Papers overview

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Highly Cited
2001
Highly Cited
2001
The mitochondrial deoxyribonucleotide (dNTP) pool is separated from the cytosolic pool because the mitochondria inner membrane is… (More)
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Highly Cited
2001
Highly Cited
2001
We have demonstrated previously the oncolytic effects of a systemically delivered, replicating vaccinia virus. To enhance the… (More)
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Highly Cited
1998
Highly Cited
1998
We report a series of studies that assess the feasibility and sensitivity of imaging of herpes virus type one thymidine kinase… (More)
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Highly Cited
1996
Highly Cited
1996
Herpes simplex virus type 1 (HSV-1) thymidine kinase is currently used as a suicide agent in the gene therapy of cancer. This… (More)
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Highly Cited
1990
Highly Cited
1990
Retroviral vectors constructed to contain the herpes simplex virus thymidine kinase (HSV-TK) gene were used for transduction of… (More)
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Highly Cited
1986
Highly Cited
1986
The lack of highly exploitable biochemical differences between normal tissues and some tumors can theoretically be circumvented… (More)
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Highly Cited
1985
Highly Cited
1985
We have characterized an in vitro transcription system derived from uninfected HeLa cells that accurately initiates RNA synthesis… (More)
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Highly Cited
1985
Highly Cited
1985
A HeLa cell transient-expression assay system was used to determine if isolated immediate early (alpha) genes from herpes simplex… (More)
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Highly Cited
1984
Highly Cited
1984
As an alternative approach to classical genetic analysis, we are investigating the potential of anti-sense (nonsense) DNA strand… (More)
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Highly Cited
1982
Highly Cited
1982
Electric impulses (8 kV/cm, 5 microseconds) were found to increase greatly the uptake of DNA into cells. When linear or circular… (More)
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