Skip to search formSkip to main contentSkip to account menu

Thymidine Kinase

Known as: EC 2.7.1.21, Kinase, Deoxypyrimidine, Kinase, Thymidine 
An enzyme that catalyzes the conversion of ATP and thymidine to ADP and thymidine 5'-phosphate. Deoxyuridine can also act as an acceptor and dGTP as… 
National Institutes of Health

Related topics

Related topics

20 relations
Enzyme GeneIn BloodPhosphorylationPhosphotransferases

Broader (1)

Phosphotransferases, ATP

Narrower (5)

TK1 protein, humanTK2 protein, humanexposed proliferation antigen 210herpes simplex thymidine kinase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1998
Highly Cited
1998
Imaging herpes virus thymidine kinase gene transfer and expression by positron emission tomography.
We report a series of studies that assess the feasibility and sensitivity of imaging of herpes virus type one thymidine kinase… 
Highly Cited
1996
Highly Cited
1996
Creation of drug-specific herpes simplex virus type 1 thymidine kinase mutants for gene therapy.
Herpes simplex virus type 1 (HSV-1) thymidine kinase is currently used as a suicide agent in the gene therapy of cancer. This… 
Highly Cited
1986
Highly Cited
1986
Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy.
The lack of highly exploitable biochemical differences between normal tissues and some tumors can theoretically be circumvented… 
Highly Cited
1985
Highly Cited
1985
Identification of immediate early genes from herpes simplex virus that transactivate the virus thymidine kinase gene.
A HeLa cell transient-expression assay system was used to determine if isolated immediate early (alpha) genes from herpes simplex… 
Highly Cited
1984
Highly Cited
1984
Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription.
Highly Cited
1982
Highly Cited
1982
Construction of poxviruses as cloning vectors: insertion of the thymidine kinase gene from herpes simplex virus into the DNA of infectious vaccinia virus.
We have constructed recombinant vaccinia viruses containing the thymidine kinase gene from herpes simplex virus. The gene was… 
Highly Cited
1982
Highly Cited
1982
Electric field mediated gene transfer.
Highly Cited
1981
Highly Cited
1981
The human beta-globin gene and a functional viral thymidine kinase gene in developing mice.
Two foreign cloned genes--one encoding a tissue-specific protein and one encoding a constitutive enzyme--were introduced into… 
Highly Cited
1981
Highly Cited
1981
The somatic replication of DNA methylation
Highly Cited
1980
Highly Cited
1980
The nucleotide sequence and transcript map of the herpes simplex virus thymidine kinase gene.
This paper presents the nucleotide sequence of the Herpes Simplex Virus thymidine kinase (tk) gene. The position on the DNA… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)